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16-Acetylgitoxin is a naturally occurring steroidal alkaloid derived from plants in the genus Digitalis, particularly the foxglove plant (Digitalis purpurea). It is a cardioactive glycoside, which means it has a positive inotropic effect on the heart, increasing the force of cardiac contractions. 16-ACETYLGITOXIN is structurally similar to digoxin, a well-known cardiac glycoside used in medicine to treat heart failure and atrial fibrillation. 16-Acetylgitoxin is characterized by the presence of an acetyl group at the 16th carbon position, which can influence its pharmacological properties. It is important to note that while these compounds have therapeutic uses, they also have a narrow therapeutic index, meaning that the difference between a safe dose and a toxic dose is small, and improper use can lead to serious side effects or even death.

7242-07-1

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7242-07-1 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 7242-07-1 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 7,2,4 and 2 respectively; the second part has 2 digits, 0 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 7242-07:
(6*7)+(5*2)+(4*4)+(3*2)+(2*0)+(1*7)=81
81 % 10 = 1
So 7242-07-1 is a valid CAS Registry Number.
InChI:InChI=1/C9H15ClO3.C9H9ClO3.C5H10N.C5H6N.Cu.H2O/c2*1-6-4-7(10)2-3-8(6)13-5-9(11)12;2*1-2-4-6-5-3-1;;/h6-8H,2-5H2,1H3,(H,11,12);2-4H,5H2,1H3,(H,11,12);1-5H2;1-4H,5H2;;1H2/q;;2*-1;+2;

7242-07-1SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 20, 2017

Revision Date: Aug 20, 2017

1.Identification

1.1 GHS Product identifier

Product name 16-O-acetylgitoxin

1.2 Other means of identification

Product number -
Other names 16-acetyl-gitoxin

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:7242-07-1 SDS

7242-07-1Downstream Products

7242-07-1Relevant academic research and scientific papers

Cardiac Glycosides. 6. Gitoxigenin C16 Acetates, Formates, Methoxycarbonates, and Digitoxosides. Synthesis and Na+, K+ -ATPase Inhibitory Activities

Hashimoto, Toshihiro,Rathore, Hargovind,Satoh, Daisuke,Hong, George,Griffin, Jane F.,et al.

, p. 997 - 1003 (2007/10/02)

A series of 17 gitoxigenin 16β-formates, acetates, and methoxycarbonates was synthesized, including their 3β-acetates, formates, and digitoxosides.A 16β-formate group was generally found to increase activity 30 times, a 16β-acetate group 9-12 times, while a 16β-methoxycarbonate decreased activity by two-thirds. 3β-Formates and acetates had little effect on activity by themselves, but sometimes reduced the activity-increasing properties of 16β-formates and acetates.A 3β-digitoxoside increases the activity of ditoxigenin by 15 times, but the effect is less ifthe 16β-group is esterified.And finally, a 16-one decreases activity dramatically.These data suggest an important role for C16 esters and possibly the presence of a separate binding site on Na+, K+ -ATPase corresponding to the cardenolide C16 position.

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