72429-30-2Relevant academic research and scientific papers
Chemical Synthesis of the Antiviral Nucleotide Analogue ddhCTP
Wood, James M.,Evans, Gary B.,Grove, Tyler L.,Almo, Steven C.,Cameron, Scott A.,Furneaux, Richard H.,Harris, Lawrence D.
, p. 8843 - 8850 (2021/06/30)
3′-Deoxy-3′,4′-didehydro-cytidine triphosphate (ddhCTP) is a novel antiviral molecule produced by the enzyme viperin as part of the innate immune response. ddhCTP has been shown to act as an obligate chain terminator of flavivirus and SARS-CoV-2 RNA-depen
The S,X-acetals in nucleoside chemistry: II. The synthesis of 3′-O-methylthiomethylribonucleosides
Pechenov,Zavgorodny,Shvets,Miroshnikov
, p. 407 - 413 (2007/10/03)
3′-O-Methylthiomethyl derivatives of ribonucleosides were synthesized from the selectively protected nucleosides by the action of a dimethyl sulfide-benzoyl peroxide mixture in acetonitrile or a dimethyl sulfoxide-acetic anhydride-acetic acid mixture.
New catalists and procedures for the dimethoxytritylation and selective silylation of ribonucleosides
Hakimelahi, Gholam H.,Proba, Zbigniew A.,Ogilvie, Kelvin K.
, p. 1106 - 1113 (2007/10/02)
Procedures have been developed for the selective formation of (a) 2',5'-silylated ribonucleosides and (b) 3',5'-silylated ribonucleosides.These procedures also permit the selective silylation at either the 2'- or 3'-position of dimethoxytritylated ribonuc
NITRATE ION AS CATALYST FOR SELECTIVE SILYLATIONS OF NUCLEOSIDES
Hakimelahi, Gholam H.,Proba, Zbigniew A.,Ogilvie, Kelvin K.
, p. 4775 - 4778 (2007/10/02)
Nitrate ion has been found to have a remarkable effect on the selectivity of silylation of ribonucleosides using the t-butyldimethylsilyl group.
HIGH YIELD SELECTIVE 3'-SILYLATION OF RIBONUCLEOSIDES
Hakimelahi, Gholam H.,Proba, Zbigniew A.,Ogilvie, Kelvin K.
, p. 5243 - 5246 (2007/10/02)
Prucedures have been developed which permit the highly selective silylation of the 3'-hydroxyl of ribonucleosides to produce 3',5'-diprotected derivatives in high yields.
