724443-34-9Relevant academic research and scientific papers
Design and synthesis of bicyclic pyrimidinones as potent and orally bioavailable HIV-1 integrase inhibitors
Muraglia, Ester,Kinzel, Olaf,Gardelli, Cristina,Crescenzi, Benedetta,Donghi, Monica,Ferrara, Marco,Nizi, Emanuela,Orvieto, Federica,Pescatore, Giovanna,Laufer, Ralph,Gonzalez-Paz, Odalys,Di Marco, Annalise,Fiore, Fabrizio,Monteagudo, Edith,Fonsi, Massimiliano,Felock, Peter J.,Rowley, Michael,Summa, Vincenzo
, p. 861 - 874 (2008)
HIV integrase is one of the three enzymes encoded by HIV genome and is essential for viral replication, but integrase inhibitors as marketed drugs have just very recently started to emerge. In this study, we show the evolution from the N-methylpyrimidinon
TETRAHYDRO-4H-PYRIDO[1,2-A]PYRIMIDINES AND RELATED COMPOUNDS USEFUL AS HIV INTEGRASE INHIBITORS
-
Page 41, (2010/02/07)
Tetrahydro-4H-pyrido[1,2-a]pyrimidines and related compounds of Formula (A): are described as inhibitors of HIV integrase and inhibitors of HIV replication, wherein n is an integer equal to zero, 1, 2 or 3, and R1, R3, R4,
