724445-35-6Relevant academic research and scientific papers
Design and synthesis of bicyclic pyrimidinones as potent and orally bioavailable HIV-1 integrase inhibitors
Muraglia, Ester,Kinzel, Olaf,Gardelli, Cristina,Crescenzi, Benedetta,Donghi, Monica,Ferrara, Marco,Nizi, Emanuela,Orvieto, Federica,Pescatore, Giovanna,Laufer, Ralph,Gonzalez-Paz, Odalys,Di Marco, Annalise,Fiore, Fabrizio,Monteagudo, Edith,Fonsi, Massimiliano,Felock, Peter J.,Rowley, Michael,Summa, Vincenzo
, p. 861 - 874 (2008/09/19)
HIV integrase is one of the three enzymes encoded by HIV genome and is essential for viral replication, but integrase inhibitors as marketed drugs have just very recently started to emerge. In this study, we show the evolution from the N-methylpyrimidinon
