724445-54-9Relevant academic research and scientific papers
PYRIMIDINONE COMPOUNDS AND METHODS FOR PREVENTING AND TREATING INFLUENZA
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Page/Page column 64, (2012/11/14)
In one aspect, the invention relates to novel, broad-spectrum anti-viral, pyrimidinone compounds, methods of use, compositions and kits useful in treating and/or preventing influenza. This abstract is intended as a scanning tool for purposes of searching
Design and synthesis of bicyclic pyrimidinones as potent and orally bioavailable HIV-1 integrase inhibitors
Muraglia, Ester,Kinzel, Olaf,Gardelli, Cristina,Crescenzi, Benedetta,Donghi, Monica,Ferrara, Marco,Nizi, Emanuela,Orvieto, Federica,Pescatore, Giovanna,Laufer, Ralph,Gonzalez-Paz, Odalys,Di Marco, Annalise,Fiore, Fabrizio,Monteagudo, Edith,Fonsi, Massimiliano,Felock, Peter J.,Rowley, Michael,Summa, Vincenzo
, p. 861 - 874 (2008/09/19)
HIV integrase is one of the three enzymes encoded by HIV genome and is essential for viral replication, but integrase inhibitors as marketed drugs have just very recently started to emerge. In this study, we show the evolution from the N-methylpyrimidinon
TETRAHYDRO-4H-PYRIDO[1,2-A]PYRIMIDINES AND RELATED COMPOUNDS USEFUL AS HIV INTEGRASE INHIBITORS
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Page 50, (2010/02/07)
Tetrahydro-4H-pyrido[1,2-a]pyrimidines and related compounds of Formula (A): are described as inhibitors of HIV integrase and inhibitors of HIV replication, wherein n is an integer equal to zero, 1, 2 or 3, and R1, R3, R4,
