724463-40-5Relevant academic research and scientific papers
d-Phenylglycinol-derived non-covalent factor Xa inhibitors: Effect of non-peptidic S4 linkage elements on affinity and anticoagulant activity
Klimkowski, Valentine J.,Watson, Brian M.,Wiley, Michael R.,Liebeschuetz, John,Franciskovich, Jeffry B.,Marimuthu, Jothirajah,Bastian, Jolie A.,Sall, Daniel J.,Smallwood, Jeffrey K.,Chirgadze, Nikolay Y.,Smith, Gerald F.,Foster, Ronald S.,Craft, Trelia,Sipes, Philip,Chastain, Marcia,Sheehan, Scott M.
, p. 5801 - 5805 (2008/03/13)
Analogs to a series of d-phenylglycinamide-derived factor Xa inhibitors were discovered. It was found that the S4 amide linkage can be replaced with an ether linkage to reduce the peptide character of the molecules and that this substitution leads to an i
FACTOR XA INHIBITORS
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Page 17; 29, (2010/02/07)
Compounds of formula (I) in which R1, n, Z, R3 and R4 have any of the meanings given in the specification, are inhibitors of the serine protease Factor Xa and are useful in the treatment of thrombotic disorders.
