724466-70-0Relevant academic research and scientific papers
Indanylacetic acid derivatives carrying 4-thiazolyl-phenoxy tail groups, a new class of potent PPAR α/γ/δ pan agonists: Synthesis, structure-activity relationship, and in vivo efficacy
Rudolph, Joachim,Chen, Libing,Majumdar, Dyuti,Bullock, William H.,Burns, Michael,Claus, Thomas,Dela Cruz, Fernando E.,Daly, Michelle,Ehrgott, Frederick J.,Johnson, Jeffrey S.,Livingston, James N.,Schoenleber, Robert W.,Shapiro, Jeffrey,Yang, Ling,Tsutsumi, Manami,Ma, Xin
, p. 984 - 1000 (2007/10/03)
Compounds that simultaneously activate the three peroxisome proliferator-activated receptor (PPAR) subtypes alpha, gamma, and delta hold potential to address the adverse metabolic and cardiovascular conditions associated with diabetes and the metabolic sy
Studies towards the conception of new selective PPARβ/δ ligands
Ekambome Bassene, Carine,Suzenet, Franck,Hennuyer, Nathalie,Staels, Bart,Caignard, Daniel-Henri,Dacquet, Catherine,Renard, Pierre,Guillaumet, Gerald
, p. 4528 - 4532 (2007/10/03)
In order to define new PPARβ/δ ligands, SAR study on the selective PPARβ/δ activator L-165,041 led to the identification of one key functional group for selective PPARβ/δ activation. Furthermore, taking advantage of SAR studies done elsewhere on the most selective PPARβ/δ ligand GW501516, the conception of new ligands showing good affinity for PPARβ/δ is reported. Finally, synthesis and biological evaluation of pyridine analogues have shown the benefical effect of the pyridine ring on the PPARβ/δ subtype selectivity.
