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[1S-, 2R-, 5R-](3-Aza-bicyclo[3.1.0]hex-2-yl)-methanol is a complex aza-bicyclic chemical compound characterized by its unique stereochemistry and the presence of a hydroxyl group. It features a specific geometric arrangement of substituents, which may contribute to its potential pharmaceutical applications.

72448-31-8

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72448-31-8 Usage

Uses

Used in Pharmaceutical Industry:
[1S-, 2R-, 5R-](3-Aza-bicyclo[3.1.0]hex-2-yl)-methanol is used as a potential pharmaceutical agent due to its distinctive molecular structure and properties. Its unique stereochemistry and the presence of a hydroxyl group may offer novel therapeutic opportunities, although further research and development are required to fully understand and harness its potential in medicinal applications.
It is important to handle and study [1S-, 2R-, 5R-](3-Aza-bicyclo[3.1.0]hex-2-yl)-methanol with caution and adhere to safety protocols, given its complex nature and potential reactivity. Further exploration of its properties and applications will be crucial in determining its role in the pharmaceutical industry.

Check Digit Verification of cas no

The CAS Registry Mumber 72448-31-8 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 7,2,4,4 and 8 respectively; the second part has 2 digits, 3 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 72448-31:
(7*7)+(6*2)+(5*4)+(4*4)+(3*8)+(2*3)+(1*1)=128
128 % 10 = 8
So 72448-31-8 is a valid CAS Registry Number.

72448-31-8SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 16, 2017

Revision Date: Aug 16, 2017

1.Identification

1.1 GHS Product identifier

Product name [1S-, 2R-, 5R-](3-Aza-bicyclo[3.1.0]hex-2-yl)-methanol

1.2 Other means of identification

Product number -
Other names (1S,2S,5R)-3-azabicyclo[3.1.0]hexan-2-ylMethanol HCl

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:72448-31-8 SDS

72448-31-8Relevant articles and documents

Novel series of pyrrolotriazine analogs as highly potent pan-Aurora kinase inhibitors

Abraham, Sunny,Hadd, Michael J.,Tran, Lan,Vickers, Troy,Sindac, Janice,Milanov, Zdravko V.,Holladay, Mark W.,Bhagwat, Shripad S.,Hua, Helen,Ford Pulido, Julia M.,Cramer, Merryl D.,Gitnick, Dana,James, Joyce,Dao, Alan,Belli, Barbara,Armstrong, Robert C.,Treiber, Daniel K.,Liu, Gang

supporting information; scheme or table, p. 5296 - 5300 (2011/10/08)

The synthesis and SAR for a novel series of pyrrolotriazines as pan-Aurora kinase inhibitors are described. Optimization of the cyclopropane carboxamide terminus of lead compound 1 resulted in analogs with high cellular activity and improved rat PK profiles. Notably, compound 17l demonstrated tumor growth inhibition in a mouse xenograft model.

AURORA KINASE COMPOUNDS AND METHODS OF THEIR USE

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Page/Page column 164, (2011/08/04)

Provided herein are pyrrolotriazine compounds for treatment of Aurora kinase mediated diseases. Also provided are pharmaceutical compositions comprising the compounds and methods of using the compounds and compositions.

CYCLOPROPYL PYRROLIDINE OREXIN RECEPTOR ANTAGONISTS

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Page/Page column 34, (2009/01/24)

The present invention is directed to cyclopropyl proline bis-amide compounds which are antagonists of orexin receptors, and which are useful in the treatment or prevention of neurological and psychiatric disorders and diseases in which orexin receptors are involved. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which orexin receptors are involved.

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