72448-31-8Relevant articles and documents
Novel series of pyrrolotriazine analogs as highly potent pan-Aurora kinase inhibitors
Abraham, Sunny,Hadd, Michael J.,Tran, Lan,Vickers, Troy,Sindac, Janice,Milanov, Zdravko V.,Holladay, Mark W.,Bhagwat, Shripad S.,Hua, Helen,Ford Pulido, Julia M.,Cramer, Merryl D.,Gitnick, Dana,James, Joyce,Dao, Alan,Belli, Barbara,Armstrong, Robert C.,Treiber, Daniel K.,Liu, Gang
supporting information; scheme or table, p. 5296 - 5300 (2011/10/08)
The synthesis and SAR for a novel series of pyrrolotriazines as pan-Aurora kinase inhibitors are described. Optimization of the cyclopropane carboxamide terminus of lead compound 1 resulted in analogs with high cellular activity and improved rat PK profiles. Notably, compound 17l demonstrated tumor growth inhibition in a mouse xenograft model.
AURORA KINASE COMPOUNDS AND METHODS OF THEIR USE
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Page/Page column 164, (2011/08/04)
Provided herein are pyrrolotriazine compounds for treatment of Aurora kinase mediated diseases. Also provided are pharmaceutical compositions comprising the compounds and methods of using the compounds and compositions.
CYCLOPROPYL PYRROLIDINE OREXIN RECEPTOR ANTAGONISTS
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Page/Page column 34, (2009/01/24)
The present invention is directed to cyclopropyl proline bis-amide compounds which are antagonists of orexin receptors, and which are useful in the treatment or prevention of neurological and psychiatric disorders and diseases in which orexin receptors are involved. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which orexin receptors are involved.