72456-88-3Relevant academic research and scientific papers
Synthesis, reactions and biological activity of 2-substituted 3-cyano-4,6-dimethylpyridine derivatives
Yassin
, p. 35 - 41 (2009)
The reaction of 2-chloro-4,6-dimethylpyridine-3-carbonitrile with hydrazine hydrate, hydroxylamine, and anthranilic acid afforded the corresponding pyrazolo, isoxazolo, and pyridoquinazoline derivatives. Alkylation of 2-mercapto-4,6-dimethylpyridine-3-carbonitrile with ethyl chloroacetate or phenacyl bromide followed by cyclization in NaOH gave thienopyridine derivatives. Diazotization of ethyl 3-amino-4,6-dimethylthieno[2,3-b]pyridine-2- carboxylate followed by the reaction with thiourea, guanidine carbonate, and hydroxylamine hydrochloride gave the corresponding thienopyridine derivatives. The biological activity of some new compounds has been discussed.
Synthesis of 4,6-dimethyl-2-thioxo-1,2-dihydropyridine-3-carbonitrile by condensation of cyanothioacetamide with acetaldehyde and 1-(Prop-1-en-2-yl)piperidine
Dyachenko,Dyachenko
, p. 32 - 36 (2017/01/11)
Three-component condensation of cyanothioacetamide with acetaldehyde and 1-(prop-1-en-2-yl)-piperidine afforded 4,6-dimethyl-2-thioxo-1,2-dihydropyridine-3-carbonitrile which was alkylated with alkyl halides to obtain substituted 2-alkylsulfanyl-4,6-dimethylpyridine-3-carbonitriles, (3-amino-4,6-dimethylthieno-[2,3-b]pyridin-2-yl)(4-cyclohexylphenyl)methanone, and 2,2′-[ethane-1,2-diylbis(sulfanediyl)]bis(4,6-dimethylpyridine-3-carbonitrile).
STUDIES WITH POLYFUNCTIONALLY SUBSTITUTED HETEROAROMATICS: NEW ROUTES FOR SYNTHESIS OF BENZOAZINES
Negm, Abdalla M.,El-Aal, Fatma Abd El-Maksoud Abd,Hafez, Ebtisam A.,Elnagdi, Mohamed H.,Mostafa, Yasser M. N.
, p. 1 - 8 (2007/10/03)
Pyridazine (I) reacts with dimethyl acetylenedicarboxylate and with N-phenyl-maleimide yielding phthalazine (II) and pyrrolophthalazine (III), respectively.Pyridine IV reacts with benzylidene malononitrile to give compound VI.Compounds VIa-c could be successfully converted into the isoquinolines XIa-c on treatment with acrylonitrile.In contrast to the behavior of arylidene malononitrile, compound IV react with N-phenylmaleimide to yield the pyrroloisoquinoline XIII.Similarly, the reaction of compound IV with each of tetracyanoethylene and dimethyl acetylenecarboxylate gave compounds XIV and XV respectively.Key words: Phthalazine, pyrrolophthalazine, isoquinoline, pyrroloisoquinoline, pyridothienopyridine.
Electrolytic Partial Fluorination of Organic Compounds. 19. A Novel Synthesis of Fluorothienopyridines Using Anodic Fluorination of Heterocyclic Sulfides as a Key Step
Erian, Ayman W.,Konno, Akinori,Fuchigami, Toshio
, p. 7654 - 7659 (2007/10/03)
Highly regioselective anodic monofluorination of 2-pyridyl and 4-pyrimidinyl sulfides bearing various electron-withdrawing groups were successfully carried out.The fluorinated sulfides were easily converted into 2-fluorothienopyridines in good yields.
