72473-85-9

Upstream product

• 541-41-3 chloroformic acid ethyl ester 
• 658702-70-6 N-[(2-methoxycarbonylbenzene)sulfenyl]benzimidazole 
• 105-56-6 ethyl 2-cyanoacetate 
• 658702-69-3 N-[(2-ethoxycarbonylbenzene)sulfenyl]benzimidazole 
• 51-17-2 benzoimidazole 
• 1972-28-7 diethylazodicarboxylate 

Downstream Products

• 1467055-80-6 diethyl 2-(4,4-dimethyl-2-(methylamino)-6-oxocyclohex-1-en-1-yl)-1H-benzo[d]imidazole-1,3(2H)-dicarboxylate 
• 1467055-79-3 diethyl 2-(2-(ethylamino)-4,4-dimethyl-6-oxocyclohex-1-en-1-yl)-1H-benzo[d]imidazole-1,3(2H)-dicarboxylate 
• 1467055-78-2 diethyl 2-(4,4-dimethyl-6-oxo-2-(propylamino)cyclohex-1-en-1-yl)-1H-benzo[d]imidazole-1,3(2H)-dicarboxylate 
• 1467055-77-1 diethyl 2-(4,4-dimethyl-6-oxo-2-(phenylamino)cyclohex-1-en-1-yl)-1H-benzo[d]imidazole-1,3(2H)-dicarboxylate 
• 1467055-76-0 diethyl 2-(2-((4-chlorobenzyl)amino)-4,4-dimethyl-6-oxocyclohex-1-en-1-yl)-1H-benzo[d]-imidazole-1,3(2H)-dicarboxylate 
• 1467055-75-9 diethyl 2-(2-(benzylamino)-4,4-dimethyl-6-oxocyclohex-1-en-1-yl)-1H-benzo[d]imidazole-1,3(2H)-dicarboxylate 
• 1467055-74-8 diethyl 2-(4,4-dimethyl-6-oxo-2-(phenethylamino)cyclohex-1-en-1-yl)-1H-benzo[d]-imidazole-1,3(2H)-dicarboxylate 
• 1467055-73-7 diethyl 2-(2-((3,4-dimethoxyphenethyl)amino)-4,4-dimethyl-6-oxocyclohex-1-en-1-yl)-1H-benzo[d]imidazole-1,3(2H)-dicarboxylate 

Relevant academic research and scientific papers

Copper-catalyzed carbonylation of anilines by diisopropyl azodicarboxylate for the synthesis of carbamates

A Cu-catalyzed efficient methodology for the direct carbonylation of anilines has been developed. The N-H bond cleavage and N-C bond formation were notably achieved under solvent-free conditions and a variety of carbamates were synthesized from readily available anilines using diisopropyl azodicarboxylate (DIAD) as the carbonylating source.

Alkylative coupling of enaminones and benzimidazole

N-Acyliminium reagents derived from benzimidazole have been used successfully in C-C bond forming reactions with β-enaminones. The new 2-substituted derivatives of 2,3- dihydrobenzimidazole are interesting both from synthetic point of view and as potentia

N-(2-Alkoxycarbonylbenzenesulfeny)benzimidazoles as nitrogen-, sulfur-, and carbon-sulfenylation reagents

N-(2-Alkoxycarbonylbenzenesulfenyl)benzimidazoles reacted with nucleophiles such as amides, imidates, thiols, Grignard reagents, and active methylene compounds to yield the corresponding sulfenylated products: N-acylsulfenamides, N-sulfenylimidates, disulfides, sulfides, and sulfenylated active methylene compounds, respectively.

α-amidoalkylation reactions and oxidation of adducts of benzimidazoles and acyl chlorides

Adducts 4 of benzimidazoles and acyl chlorides were successfully used as electrophilic reagents in an intermolecular α-amidoalkylation reaction toward ketones for synthesis of 2-(2-oxoalkyl)-1,3-diacyl-2,3- dihydrobenzimidazoles 6 and oxidized with KMnO4 to 1,3-diacyl-2,3- dihydrobenzimidazol-2-ones 7.

The reaction of benzimidazolium derivatives with superoxide

1-Ethoxycarbonyl-3-methylbenzimidazolium salts, which have an electron deficient imidazolium ring and a carbamate moiety, were allowed to react with superoxide to give ring-opened products and 1-methylbenzimidazoles. The products ratio varied on the change of the counter cation species of superoxide. When 1,1',3,3'-tetramethyl-2,2'-bibenzimidazolium salt reacted with KO2, chemiluminescence was observed which did not occur by the use of KOH or H2O2 as a reagent.