724734-00-3

Upstream product

• 213028-88-7 1-O-acetyl-3,4,6-tri-O-benzyl-α,β-D-glucopyranose 
• 447408-21-1 6-methyl-12,13-dihydropyrrolo[2,3-a]pyrrolo[3,4-c]pyrido[3',2':4,5]carbazole-5,7-dione 
• 724733-99-7 1-chloro-1-deoxy-2-O-tosyl-3,4,6-tri-O-benzyl-α-D-glucopyranose 

Relevant academic research and scientific papers

Synthesis of bridged aza-rebeccamycin analogues

The syntheses of rebeccamycin analogues possessing a 7-azaindole moiety instead of an indole unit, and with both indole and azaindole moieties linked to the carbohydrate are described. In these bridged aza compounds, the oxygen of the pyranose heterocycle is oriented towards either the indole, or the azaindole unit. In these series, compounds bearing a free imide nitrogen were synthesized by coupling the corresponding aglycones with a sugar pre-tosylated in 2-position via a Mitsunobu reaction. To obtain a precursor for bridged aza-rebeccamycin analogues substituted in 6-position on the sugar moiety, a 2,6-ditosylated sugar was used.

Synthesis of a staurosporine analogue possessing a 7-azaindole unit instead of an indole moiety

The synthesis of a new staurosporine analogue possessing a 7-azaindole unit instead of an indole moiety is described. This synthesis could be achieved by coupling a sugar moiety previously tosylated in 2′ position to the azaindolocarbazole aglycone. Nucle