724740-80-1Relevant academic research and scientific papers
Cheap and efficient protocol for the synthesis of tetrahydroquinazolinone, dihydropyrimidinone, and pyrimidinone derivatives
Mirza-Aghayan, Maryam,Moradi, Alireza,Bolourtchian, Mohammad,Boukherroub, Rabah
, p. 8 - 20 (2010)
The article reports a practical, simple, and inexpensive procedure for the synthesis of tetrahydroquinazolinone and dihydropyrimidinone derivatives from aldehydes, cyclic ketones, and urea using a catalytic amount of ammonium chloride or lithium perchlorate. The protocol provides good yields and simple workup procedure for the products. By this method, we have prepared and characterized the 4-aryl-3,4,5,6-tetrahydrobenzo[h]quinazolin-2(1H)-one (3a, c, d, f, g, j, k), 4-aryl-3,4-dihydro-1H-indeno[1,2-d]pyrimidin-2(5H)-one (3b, e, h, i), 4-aryl-5,6-dihydrobenzo[h]quinazolin-2(3H)-one (3j', k', l'), and 4-aryl-3,5-dihydro-2H-indeno[1,2-d]pyrimidin-2-one (3i', m', n', o', p') derivatives. Furthermore, we have synthesized the pyrimidinone derivatives (6a'-e') using a catalytic amount of cupric chloride from aldehydes, acyclic ketones and urea. The tautomeric interconversion of pyrimidinone derivatives 6a'-e'6a''-e'' has been observed.
