724745-11-3Relevant academic research and scientific papers
Synthesis of pyrazolines by a site isolated resin-bound reagents methodology
Gembus, Vincent,Bonnet, Jean-Jacquesrouen,Janin, Franoisrouen,Bohn, Pierre,Levacher, Vincent,Briere, Jean-Franois
experimental part, p. 3287 - 3293 (2010/08/21)
The elaboration of biologically important 3,4-substituted pyrazolines was achieved by an organocatalysed aza-Michael/transimination domino sequence between hydrazones and enones making use of a mixture of heterogeneous resin-bound acid/base reagents. This methodology nicely illustrates the site isolation concept of supported reagents allowing the simultaneous use of otherwise destructive reactive functionalities. The Royal Society of Chemistry 2010.
