724767-52-6Relevant academic research and scientific papers
Asymmetric Assembly of All-Carbon Tertiary/Quaternary Nonadjacent Stereocenters through Organocatalytic Conjugate Addition of α-Cyanoacetates to a Methacrylate Equivalent
Iriarte, Igor,Vera, Silvia,Badiola, Eider,Mielgo, Antonia,Oiarbide, Mikel,García, Jesús M.,Odriozola, José M.,Palomo, Claudio
supporting information, p. 13690 - 13696 (2016/09/13)
An efficient, highly diastereo- and enantioselective assembly of acyclic carbonyl fragments possessing nonadjacent all-carbon tertiary/quaternary stereoarrays is reported based on a Br?nsted base catalyzed Michael addition/α-protonation sequence involving α-cyanoacetates and 2,4-dimethyl-4-hydroxypenten-3-one as novel methacrylate equivalent.
Mechanistic consideration of asymmetric CN and CC bond formations with bifunctional chiral ir and ru catalysts
Hasegawa, Yasuharu,Gridnev, Ilya D.,Ikariya, Takao
supporting information; experimental part, p. 316 - 334 (2012/05/07)
The mechanism of two enantioselective reactions, direct amination of α-cyanoacetates 3 with azodicarboxylates 4 and CC bond formation reaction of α-cyanoacetates with acetylenic esters 6, catalyzed by chiral bifunctional Ir and Ru complexes, Cp*Ir[(S,S)-N
Enantioselective bimetallic catalysis of michael additions forming quaternary stereocenters
Jautze, Sascha,Peters, Rene
supporting information; experimental part, p. 9284 - 9288 (2009/05/15)
Robotlike: Low catalyst loadings of a planar-chiral ferrocenyl bispalladacycle are sufficient to catalyze the Michael addition of trisubstituted α-cyanoacetates to enones with excellent yields (TONs up to 2450) and high enantioselectivity. The reaction proceeds by a cooperative bimetallic mechanism and is superior to previous methods relying on soft Lewis acid catalysts. (Chemical Equation Presented)
Enantioselective direct amination of α-cyanoacetates catalyzed by bifunctional chiral Ru and Ir amido complexes
Hasegawa, Yasuharu,Watanabe, Masahito,Gridnev, Ilya D.,Ikariya, Takao
, p. 2158 - 2159 (2008/09/18)
The bifunctional chiral amido Ir complex catalyzed asymmetric electrophilic direct amination of α-substituted α-cyanoacetates using azodicarboxylates proceeds rapidly to provide the corresponding hydrazine adducts in high yields and with excellent ee values. Copyright
