7248-26-2 Usage
Uses
Used in Laboratory Applications:
2-hydroxynaphthalene-1-carbohydrazide is used as a reagent for the determination of certain metal ions, facilitating the analysis and detection of these elements in various samples.
Used in Photographic Industry:
In the development of photographic films and papers, 2-hydroxynaphthalene-1-carbohydrazide is utilized for its ability to enhance the quality and performance of the final products.
Used in Medical Research:
2-hydroxynaphthalene-1-carbohydrazide is studied for its potential applications in medicine, including the development of new drugs and therapies, due to its interesting chemical and biological properties.
Used in Agricultural Research:
2-hydroxynaphthalene-1-carbohydrazide is also being investigated for its possible uses in agriculture, such as the development of new pesticides or fertilizers, leveraging its unique chemical characteristics.
However, it is crucial to handle 2-hydroxynaphthalene-1-carbohydrazide with care, as it may cause irritation to the skin, eyes, and respiratory system, and can be harmful if ingested. Proper safety measures should be taken to minimize any potential risks associated with its use.
Check Digit Verification of cas no
The CAS Registry Mumber 7248-26-2 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 7,2,4 and 8 respectively; the second part has 2 digits, 2 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 7248-26:
(6*7)+(5*2)+(4*4)+(3*8)+(2*2)+(1*6)=102
102 % 10 = 2
So 7248-26-2 is a valid CAS Registry Number.
7248-26-2Relevant academic research and scientific papers
Misko, Tessianna A.,Liu, Yi-Ting,Harris, Michael E.,Oleinick, Nancy L.,Pink, John,Lee, Hsueh-Yun,Dealwis, Chris G.
, p. 438 - 450 (2019)
Ribonucleotide reductase (RR) catalyses the rate-limiting step of dNTP synthesis, establishing it as an important cancer target. While RR is traditionally inhibited by nucleoside-based antimetabolites, we recently discovered a naphthyl salicyl acyl hydrazone-based inhibitor (NSAH) that binds reversibly to the catalytic site (C-site). Here we report the synthesis and in vitro evaluation of 13 distinct compounds (TP1-13) with improved binding to hRR over NSAH (TP8), with lower KD’s and more predicted residue interactions. Moreover, TP6 displayed the greatest growth inhibiting effect in the Panc1 pancreatic cancer cell line with an IC50 of 0.393 μM. This represents more than a 2-fold improvement over NSAH, making TP6 the most potent compound against pancreatic cancer emerging from the hydrazone inhibitors. NSAH was optimised by the addition of cyclic and polar groups replacing the naphthyl moiety, which occupies the phosphate-binding pocket in the C-site, establishing a new direction in inhibitor design.
