72482-70-3

Basic information

• Product Name: 5-chloro-3-(2-fluorophenyl)-6-methoxy-1,2-benzisoxazole
• Synonyms: 5-chloro-3-(2-fluorophenyl)-6-methoxy-1,2-benzisoxazole
• CAS NO: 72482-70-3
• Molecular Weight: 277.682
• Mol File: 72482-70-3.mol

Chemical Properties

• CAS DataBase Reference: 5-chloro-3-(2-fluorophenyl)-6-methoxy-1,2-benzisoxazole(CAS DataBase Reference)
• NIST Chemistry Reference: 5-chloro-3-(2-fluorophenyl)-6-methoxy-1,2-benzisoxazole(72482-70-3)
• EPA Substance Registry System: 5-chloro-3-(2-fluorophenyl)-6-methoxy-1,2-benzisoxazole(72482-70-3)

Safety Data

• Hazardous Substances Data: 72482-70-3(Hazardous Substances Data)

Upstream product

• 72582-58-2 (2,5-Dichloro-4-methoxy-phenyl)-(2-fluoro-phenyl)-methanone oxime 
• 72482-69-0 2,5-dichloro-4-(2-fluorobenzoyl)anisole 
• 7051-13-0 1-chloro-2,4-dimethoxybenzene 
• 130556-06-8 4-chloro-2-(2-fluorobenzoyl)-5-methoxyphenol 
• 151-10-0 1,3-Dimethoxybenzene 

Downstream Products

• 72482-71-4 5-chloro-3-(2-fluorophenyl)-6-hydroxy-1,2-benzisoxazole 
• 72482-73-6 {[5-chloro-3-(2-fluorophenyl)-1,2-benzisoxazol-6-yl]oxy}acetic acid 
• 72482-72-5 [5-Chloro-3-(2-fluoro-phenyl)-benzo[d]isoxazol-6-yloxy]-acetic acid ethyl ester 
• 107804-56-8 5-chloro-7,8-dihydro-3-(2-fluorophenyl)furo[2,3-g]-1,2-benzisoxazole-7-carboxylic acid 
• 107804-55-7 5-chloro-7,8-dihydro-3-(2-fluorophenyl)furo[2,3-g]-1,2-benzisoxazole-7-methanol 
• 136741-80-5 6-Allyloxy-5-chloro-3-(2-fluoro-phenyl)-benzo[d]isoxazole 
• 107804-74-0 7-Allyl-5-chloro-3-(2-fluoro-phenyl)-benzo[d]isoxazol-6-ol 

Relevant articles and documents

Studies on uricosuric diuretics. II. Substituted 7,8-dihydrofuro[2,3-g]-1,2-benzisoxazole-7-carboxylic acids and 7,8-dihydrofuro[2,3-g]benzoxazole-7-carboxylic acids

A series of substituted 7,8-dihydrofuro[2,3-g]-1,2-benzisoxazole-7-carboxylic acids and 7,8-dihydrofuro[2,3-g]benzoxazole-7-carboxylic acids were synthesized and evaluated for uricosuric and diuretic activities in rats. Many of the benzisoxazole derivatives showed uricosuric and only weak diuretic activities, whereas the benzoxazoles exhibited potent diuretic activities with little affecting urate excretion. Among these compounds, 5-chloro-7,8-dihydro-3-phenylfuro[2,3-g]-1,2-benzisoxazole-7-carboxylic acid (AA-193) was found to be a potent uricosuric agent without diuretic activity and was selected for further development.

1,2-benzisoxazoloxyacetic acids and related compounds

Novel 1,2-benzisoxazoloxyacetic acids and related compounds, methods for preparing same and methods of treatment by administering compositions containing such a compound are described. These compounds are useful as diuretic, uricosuric and antihypertensive agents.

acetic Acids. A New Diuretic Series

A series of acetic acids was synthesized and tested for diuretic activity in saline-loaded mice and in conscious, water-loaded dogs.The structural requirements for good diuretic activity in both mice and dogs were found