7249-12-9

Basic information

• Product Name: 2,4,6-tris(4-methylpiperazin-1-yl)-1,3,5-triazine
• CAS NO: 7249-12-9
• Molecular Formula: C₁₈H₃₃N₉
• Molecular Weight: 375.5149
• Mol File: 7249-12-9.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 536.9°C at 760 mmHg
• Flash Point: 278.5°C
• Density: 1.176g/cm³
• Vapor Pressure: 1.34E-11mmHg at 25°C
• Refractive Index: 1.578
• CAS DataBase Reference: 2,4,6-tris(4-methylpiperazin-1-yl)-1,3,5-triazine(CAS DataBase Reference)
• NIST Chemistry Reference: 2,4,6-tris(4-methylpiperazin-1-yl)-1,3,5-triazine(7249-12-9)
• EPA Substance Registry System: 2,4,6-tris(4-methylpiperazin-1-yl)-1,3,5-triazine(7249-12-9)

Safety Data

• Hazardous Substances Data: 7249-12-9(Hazardous Substances Data)

Usage

Chemical structure

A heterocyclic compound containing three piperazine groups attached to a central triazine ring.

Use in pharmaceutical industry

Serves as a precursor for the synthesis of various biologically active compounds.

Affinity towards receptors

Has a high affinity towards certain receptors in the central nervous system.

Potential for drug development

May be used in the development of new drugs for neurological disorders.

Anti-cancer properties

Has been studied for its ability to inhibit certain enzymes involved in cancer cell proliferation.

Diverse potential applications

Has potential applications in the field of medicine and drug development.

Upstream product

• 109-01-3 1-methyl-piperazine 
• 108-77-0 1,3,5-trichloro-2,4,6-triazine 

Relevant articles and documents

Synthesis and cytotoxicity evaluation of (tetrahydro-β-carboline)-1,3,5-triazine hybrids as anticancer agents

A series of tetrahydro-β-carbolines and 1,3,5-triazine hybrids have been synthesized and evaluated for their cytotoxicity against a panel of eight human cancer cell lines and normal human fibroblasts (NIH3T3). It led us to discovery of racemic compounds 69, 71 and 75, which are selectively cytotoxic towards KB (oral cancer) cell line with IC50 values of 105.8, 664.7 and 122.2?nM, respectively; while their enantiopure forms are less active and not selective. Enantiopure compound 42 showed 2.5 times more selectivity towards MCF7 cells over normal fibroblast NIH3T3 cells with an IC50 value of 740?nM, also arrests cell cycle in G1 phase and induces apoptosis in MCF7 and MDA MB231cell lines.