7249-30-1Relevant academic research and scientific papers
Design and synthesis of novel antibacterial agents with inhibitory activity against DNA polymerase III
Ali, Amjad,Aster, Susan D.,Graham, Donald W.,Patel, Gool F.,Taylor, Gayle E.,Tolman, Richard L.,Painter, Ronald E.,Silver, Lynn L.,Young, Katherine,Ellsworth, Kenneth,Geissler, Wayne,Harris, Georgianna S.
, p. 2185 - 2188 (2007/10/03)
4-Substituted 2-amino-6-(anilino)pyrimidines have been found to be selective inhibitors of DNA polymerase III, a replicative enzyme known to be essential in the DNA synthesis of Gram-positive bacteria. Among the analogues, 18 displayed an IC50 of 10 μM against DNA polymerase III from Staphylococcus aureus.
Haloanilino derivatives of pyrimidines, purines, and purine nucleoside analogs: Synthesis and activity against human cytomegalovirus
Medveczky,Yang,Gambino,Medveczky,Wright
, p. 1811 - 1819 (2007/10/02)
2-Anilinopurines and 6-anilinopyrimidines bearing 3,4- or 3,5-dichloro substituents in the anilino ring inhibited virus-specific DNA synthesis by human cytomegalovirus (HCMV)-infected human embryonic lung (HEL) cells in culture. In general, active compounds had moderate to low selectivity for viral vs host cell DNA synthesis. Nucleoside and acyclonucleoside analogs of 2-(3,5-dichloroanilino)purines inhibited both HCMV and cellular DNA synthesis at similar concentrations. 2-Amino-4-chloro-6-(3,5- dichloroanilino)pyrimidine and several related compounds inhibited HCMV growth in yield reduction assays at concentrations that were nontoxic to HEL cells.
