725223-47-2

Upstream product

• 98796-53-3 N₆-benzoyl-5'-O-(4,4'-dimethoxytrityl)-2'-deoxyadenosine-3'-O-[O-(2-cyanoethyl)-N,N'-diisopropylphosphoramidite] 
• 107-13-1 acrylonitrile 

Relevant academic research and scientific papers

Solution stability and degradation pathway of deoxyribonucleoside phosphoramidites in acetonitrile

The impuritiy profiles of acetonitrile solutions of the four standard O-cyanoethyl-N,N-diisopropyl-phosphoramidites of 5′-O-dimethoxytrityl (DMT) protected deoxyribonucleosides (dGib, dAbz, dC bz, T) were analyzed by HPLC-

Stereoselective synthesis of alkylphosphonates: A facile rearrangement of cyanoethyl-protected nucleoside phosphoramidites

Cyanoethyl-protected nucleoside phosphoramidites undergo a facile Michaelis-Arbuzov reaction upon addition of acrylonitrile to afford cyanoethyl phosphonates. This rearrangement is stereoselective at room temperature, but racemization is observed at high temperatures, indicating two different pathways. A plausible mechanism is proposed for this reaction.