72525-55-4Relevant academic research and scientific papers
Metalation of o-Halostyrene Oxides. Preparation of Benzocyclobutenols
Akguen, Eyup,Glinski, Margaret B.,Dhawan, Kasturi L.,Durst, Tony
, p. 2730 - 2734 (2007/10/02)
o-Bromo- and o-iodostyrene oxides are converted in fair to good yield to benzocyclobutenols upon treatment with n-BuLi and MgBr2 in THF or ether at -78 deg C, followed by warming to room temperature.The reaction involves initial halogen-lithium exchange followed either by MgBr2-initiated opening of the epoxide function to a haloalkoxide or rearrangement of the epoxide function to a ketone or aldehyde followed by cyclization.Benzocyclobutenol formation was not successful in the case of o-halostilbene oxides.
Preparation of Benzocyclobutenols from o-Halostyrene Oxides
Dhawan, Kasturi L.,Gowland, Barbara D.,Durst, Tony
, p. 922 - 924 (2007/10/02)
Reaction of several o-bromo- and o-iodostyrene oxides, dissolved in THF at -78 deg C containing a suspension of MgBr2, with n-BuLi gave benzocyclobutenols in 50-83 percent yield.
