725252-08-4

Upstream product

• 120-72-9 indole 
• 148249-36-9 3-bromo-1-(1,1,1-triisopropylsilyl)-1H-indole 
• 123191-00-4 1-(triisopropylsilyl)-1H-indole 
• 725252-07-3 (5R,6R)-6-(1H-indol-3-yl)-2-methyl-5-(prop-1-en-2-yl)cyclohex-2-enone 
• 6485-40-1 (R)-Carvone 

Relevant academic research and scientific papers

Enantiospecific total synthesis of the hapalindoles, fischerindoles, and welwitindolinones via a redox economic approach

Full details are provided for the total synthesis of several members of the hapalindole family of natural products, including hapalindole Q, 12-epi-hapalindole D, 12-epi-fischerindole U, 12-epi-fischerindole G, 12-epi-fischerindole I, and welwitindolinone

Direct coupling of indoles with carbonyl compounds: Short, enantioselective, gram-scale synthetic entry into the hapalindole and fischerindole alkaloid families

The invention of a method for the direct union of indoles and carbonyl compounds (ketones, amides, esters) is described. Using this new method, a short, enantioselective, gram-scale and protecting group-free synthetic entry to the fischerindole and hapali

Synthesis and absolute configuration of (+)-hapalindole Q

The versatility of brominated camphor derivatives as six-membered-ring chiral building blocks in the synthesis of compounds of mixed biogenesis has been demonstrated in an eight-step synthesis of (+)-hapalindole Q from (+)-(1R)-9-bromocamphor in an overall 8% yield which confirms the absolute stereochemistry to be 10R, 11R, 12R, 15R.