72527-24-3

Upstream product

• 109400-46-6 2-(3-Bromo-4-methoxyphenyl)-N-<2-(3,4-dimethoxyphenyl)-ethyl>-acetamide 
• 72527-20-9 2-(3-Bromo-4-methoxy-phenyl)-N-[2-(3,4-dimethoxy-phenyl)-ethyl]-thioacetamide 
• 774-81-2 (3-bromo-4-methoxy-phenyl)-acetic acid 
• 19626-36-9 methyl 2-(3-bromo-4-methoxyphenyl)acetate 
• 104-01-8 4-Methoxyphenylacetic acid 

Downstream Products

• 72527-30-1 1-(3-Bromo-4-methoxy-benzyl)-6,7-dimethoxy-2-methyl-3,4-dihydro-isoquinolinium; iodide 
• 117566-02-6 1-(3-Bromo-4-methoxybenzyl)-1,2,3,4-tetrahydro-6,7-dimethoxyisoquinoline 
• 70400-29-2 (+/-)-1-(3-bromo-4-methoxy-benzyl)-6,7-dimethoxy-2-methyl-1,2,3,4-tetrahydro-isoquinoline 

Relevant academic research and scientific papers

SYTHESIS OF N-(ARYLETHYL)ARYLTHIOACETAMIDES BY THE WILLGERODT-KINDLER REACTION AND THEIR CONVERSION TO SUBSTITUTED 1-BENZYL-1,2,3,4-TETRAHYDROISOQUINOLINES

N-(Arylethyl)arylthioacetamides were synthesized by the reaction of substituted acetophenones with 2-arylethylamines.The reaction gives good yields when compounds with substituted hydroxyl groups are used. 2,4-Diarylthiazoles were isolated as side products from the Wilgerodt-Kindler reaction.The thioamides were converted into substituted 1-benzyl-1,2,3,4-tetrahydroisoquinolines by the Bischler-Napieralski cyclization, N-methylation, and reduction of the corresponding 3,4-dihydroisoquinoline methiodide derivatives.