72535-68-3

Upstream product

• 64-17-5 ethanol 
• 128799-82-6 N¹-Tosyl-N¹-(p-chlorophenyl)-N²-(p-methoxyphenyl)acetamidine 
• 134899-73-3 N¹-Mesyl-N¹-(p-nitrophenyl)-N²-(p-methoxyphenyl)acetamidine 
• 134899-71-1 N-{1-[(E)-4-Methoxy-phenylimino]-ethyl}-N-(4-nitro-phenyl)-benzenesulfonamide 
• 130117-82-7 N¹-Tosyl-N¹-(p-nitrophenyl)-N²-(p-methoxyphenyl)acetamidine 
• 134899-72-2 4-Chloro-N-{1-[(E)-4-methoxy-phenylimino]-ethyl}-N-(4-nitro-phenyl)-benzenesulfonamide 
• 134899-70-0 N-(4-Cyano-phenyl)-N-{1-[(E)-4-methoxy-phenylimino]-ethyl}-3-nitro-benzenesulfonamide 
• 134899-69-7 N-{1-[(E)-4-Methoxy-phenylimino]-ethyl}-3-nitro-N-(3-nitro-phenyl)-benzenesulfonamide 
• 134899-63-1 N¹-(m-Nitrobenzenesulfonyl)-N¹-(p-nitrophenyl)-N²-(p-methoxyphenyl)acetamidine 
• 134899-68-6 N-{1-[(E)-4-Methoxy-phenylimino]-ethyl}-3-nitro-N-(4-trifluoromethyl-phenyl)-benzenesulfonamide 
• 2475-92-5 4-methoxyacetophenone oxime 

Downstream Products

• 71709-26-7 N,N'-bis-(4-methoxy-phenyl)-acetamidine 
• 22365-62-4 N¹,N²-di(4-chlorophenyl)acetamidine 
• 128915-04-8 N¹-(p-methoxyphenyl)-N²-(p-chlorophenyl)acetamidine 

Relevant academic research and scientific papers

Amidines. I. Hydrolysis of N1-acyl- and N1-tosyl-N1,N2-diarylamidines

In acid hydrolysis of N1-acyl-N1,N2-diarylamidines, a water molecule attacked exclusively the amidine central carbon, and the reaction proceeded in parallel through two pathways. One of them leads to the formation of two N-acylarylamines, and the other leads to the formation of N,N-diacylarylamine and arylamine. Acid hydrolysis of N1-tosyl-N1,N2-diarylamidine was also examined. The results were similar to those of the hydrolysis of N1-acyl-N1,N2-diarylamidines. Alkaline hydrolysis and alcoholysis of N1-acyl-N1,N2-diarylamidines occurred almost exclusively at the amide carbonyl group to give N1,N2-diarylamidines and carboxylic acids or their esters. The effects of structural change and the aryl substituents on the rate and direction of the reaction were examined.