7256-03-3

Basic information

• Product Name: 2-amino-9H-fluoren-1-ol
• Synonyms: Fluoren-1-ol, 2-amino-
• CAS NO: 7256-03-3
• Molecular Formula: C₁₃H₁₁NO
• Molecular Weight: 197.2325
• Mol File: 7256-03-3.mol

Chemical Properties

• Boiling Point: 391.3°C at 760 mmHg
• Flash Point: 190.4°C
• Density: 1.323g/cm³
• Vapor Pressure: 1.1E-06mmHg at 25°C
• Refractive Index: 1.736
• CAS DataBase Reference: 2-amino-9H-fluoren-1-ol(CAS DataBase Reference)
• NIST Chemistry Reference: 2-amino-9H-fluoren-1-ol(7256-03-3)
• EPA Substance Registry System: 2-amino-9H-fluoren-1-ol(7256-03-3)

Safety Data

• Hazardous Substances Data: 7256-03-3(Hazardous Substances Data)

Usage

Chemical group

Amines

Physical state

Pale yellow solid

Molecular weight

197.23 g/mol

Uses

Building block in synthesis of pharmaceuticals, agrochemicals, and dyes; precursor in organic chemistry reactions

Hazards

Suspected human carcinogen and mutagen; exposure should be avoided or limited

Upstream product

• 6344-59-8 2-Nitro-fluorenol-(1) 

Relevant articles and documents

IL-8 RECEPTOR ANTAGONISTS

The present invention relates to novel compounds and a novel use of phenyl ureas in the treatment of disease states mediated by the chemokine Interleukin-8 (IL-8).

IL-8 RECEPTOR ANTAGONISTS

This invention relates to the novel use of phenyl ureas in the treatment of disease states mediated by the chemokine, Interleukin-8 (IL-8).

IL-8 RECEPTOR ANTAGONISTS

This invention relates to novel compounds and a novel use of phenyl ureas in the treatment of disease scates mediated by the chemokine, Interleukin-8 (IL-8). In particular, this invention relates to the novel compounds of Formula (Ia) and their use in treating chemokine mediated diseases wherein the chemokine binds to an IL-8 a or b receptor. Compounds of Formula (Ia) are represented by the structure: STR1 wherein interalia, X is oxygen or sulfur;Rb is NR 6 R. sub.7, alkcyl, aryl, arylC 1-4 alkyl, aryl C 2-4 alkenyl, heteroaryl, heteroarylC 1-4 alkyl, heteroarylC 2-4 alkenyl, heterocyclic or heterocyclic C 1-4 alkyl, or a heterocyclic C 2-4 alkenyl moiety, camphor, all of which may be optionally substituted; R 1 is independently selected from hydrogen; halogen; nitro; cyano; C 1-10 alkyl; halosubstituted C 1-10 alkyl; C 2-10 alkoxy; halosubstituted C 1-10 alkoxy; azide; (CR. sub.8 R 8)q S(O) t R 4 ; hydroxy; hydroxy substituted C 1-4 alkyl; aryl; aryl C 1-4 alkyl; aryl C 2-10 alkenyl; aryloxy; aryl C 1-4 alkyloxy; heteroaryl; heteroarylalkyl; heteroaryl C 2-10 alkenyl; heteroaryl C 1-4 alkyloxy; heterocyclic; heterocyclic C 1-4 alkyl; heterocyclicC 1-4 alkyloxy; heterocyclic C 2-10 alkenyl; q is 0 or an integer having a value of 1 to 10; n is an integer having a value of 1 to 3;m is an integer having a value of 1 to 3; Y is hydrogen; halogen; nitro; cyano; halosubstituted C 1-10 alkyl; C 1-10 alkyl; C 2-10 alkenyl C. sub.1-10 alkoxy; halosubstituted C 1-10 alkoxy; azide; (CR 8 R. sub.8)qS(O) t R 4, (CR 8 R 8)qOR 4 ; hydorxy; hydroxy substituted C. sub.1-4 alkyl; aryl; aryl C 1-4 alkyl; aryloxy; arylC. sub.1-4 alkyloxy; aryl C 2-10 alkenyl; heteroaryl; heteroarylalkyl; heteroaryl C 1-4 alkyloxy; heteroaryl C 2-10 alkenyl; heterocyclic, heterocyclic C 1-4 alkyl; heterocyclicC 2-10 alkenyl;or a pharmaceutically acceptable salt thereof.