72569-10-9

Usage

Physical Properties

Colorless, odorless solid

+ Sunless tanning products

reacts with amino acids in the skin to produce a tan-like color
+ Coloring agent in food and beverage industry
+ Reagent in chemical synthesis

Safety

Considered safe and effective, approved by FDA for use in cosmetic products

Industry Applications

Used in cosmetic, food and beverage, and chemical industries

Upstream product

• 630-18-2 tert-butyl isocyanide 
• 6793-92-6 p-benzyloxyphenylbromide 
• 27914-73-4 4-acetoxybenzoyl chloride 

Downstream Products

• 1371591-89-7 4-(5-{(1R)-1-[4-(2,2-dimethylpropanoyl)phenoxy]propyl}-1,2,4-oxadiazol-3-yl)-2-fluorobenzoic acid 
• 1371591-87-5 tert-butyl 4-(5-{(1R)-1-[4-(2,2-dimethylpropanoyl)phenoxy]propyl}-1,2,4-oxadiazol-3-yl)-2-fluorobenzoate 
• 117039-52-8 1-[4-(3-{4-[Bis-(4-fluoro-phenyl)-hydroxy-methyl]-piperidin-1-yl}-propoxy)-phenyl]-2,2-dimethyl-propan-1-one; compound with (E)-but-2-enedioic acid 
• 117022-49-8 1-[4-(3-Chloro-propoxy)-phenyl]-2,2-dimethyl-propan-1-one 

Relevant academic research and scientific papers

HCV POLYMERASE INHIBITORS

The invention provides compounds of the formula:wherein B is a nucleobase selected from the groups (a) to (d):and the other variables are as defined in the claims, which are of use in the treatment or prophylaxis of hepatitis C virus infection, and related aspects.

DIOXOLANE ANALOGUES OF URIDINE FOR THE TREATMENT OF CANCER

The invention provides compounds of formula (I), wherein: R1 is OR11, or NR5R5'; R2 is H or F; R5 is H, C1-C6alkyl, OH, C(=O)R6, O(C=O)R6 or O(C=O)OR6; R5′ is H or C1-C6alkyl; R6 is C1-C6alkyl or C3-C7cycloalkyl; R13 is H, phenyl, pyridyl, benzyl, indolyl or naphthyl wherein the phenyl, pyridyl, benzyl, indolyl and naphthyl is optionally substituted with 1, 2 or 3 R22; and the other variables are as defined in the claims, which are of use in the treatment of cancer, and related aspects.

HCV POLYMERASE INHIBITORS

The invention provides compounds of the formula:(I) wherein B is a nucleobase selected from the groups (a) to (d) and the other variables are as defined in the claims, which are of use in the treatment or prophylaxis of hepatitis C virus infection, and related aspects.

HCV POLYMERASE INHIBITORS

The invention provides compounds of the formula (I) wherein B is a nucleobase selected from the groups (a) to (d): and the other variables are as defined in the claims, which are of use in the treatment or prophylaxis of hepatitis C virus infection, and related aspects.

ACYLBENZENE DERIVATIVE

Provided are compounds having an excellent hypoglycemic action and a β cell- or pancreas-protecting action or a pharmaceutically acceptable salt thereof, and a pharmaceutical composition having an excellent therapeutic effect and/or prophylactic effect on type 1 diabetes, type 2 diabetes, and the like, which cause an increase in the blood sugar level due to abnormal sugar metabolism. A compound represented by general formula (I), or a pharmaceutically acceptable salt thereof, is disclosed.

Steric and pH Effects on the Rate of Dakin Oxidation of Acylphenols

The rates of hydrogen peroxide oxidation of a series of o- and p-acylphenols with a variety of aliphatic substituents on the carbonyl carbon have been measured over a range of alkaline pH conditions. p-Hydroxypivalophenone was here synthesized for the first time, to complete this series.Relative rates of Dakin oxidation appear to be more strongly affected by the bulk of the aliphatic carbonyl substituent than those found for parallel alkaline ester hydrolyses and somewhat less strongly than those forperbenzoic acid oxidations.Correlations of oxidation rate with pH show a double maximum and a high rate throughout the pH range 9.5-13.5 for o-hydroxyacetophenone and a single maximum of about half the ortho rates over the narrower pH range of 11.5-13.5 for p-hydroxyacetophenone.Unimolecular involvement of undissociated hydrogen peroxide in the rate-determining step of the lower pH maximum for o-hydroxyacetophenone and of hydroperoxide anion in the high-pH maximum for both o- and p-hydroxyacetophenone is one explanation consistent with the observed results.