725698-76-0Relevant academic research and scientific papers
Synthesis, antifungal activity and QSAR study of 2-arylhydroxynitroindoles
Kokurkina, Galina V.,Dutov, Mikhail D.,Shevelev, Svyatoslav A.,Popkov, Sergey V.,Zakharov, Alexey V.,Poroikov, Vladimir V.
, p. 4374 - 4382 (2011/11/12)
A series of 2-arylhydroxynitroindoles were prepared and tested for antifungal activity in vitro. The preliminary bioassays indicated that some compounds are comparable to the commercial fungicide (triadimefon). To further explore the structure-activity re
Intramolecular cyclization of O-(3,5-dinitrophenyl) and O-(3-amino-5-nitrophenyl) ketoximes, products of transformations of 1,3,5-trinitrobenzene. the synthesis of nitrobenzo[b]furans and 4-hydroxynitroindoles
Vorob'ev,Dutov,Vatsadze,Petrosyan,Kachala,Strelenko,Shevelev
, p. 1020 - 1027 (2008/09/17)
O-(3,5-Dinitrophenyl) ketoximes obtained in the reactions of ketoximes with 1,3,5-trinitrobenzene undergo acid-catalyzed cyclization into 2-substituted or 2,3-disubstituted 4,6-dinitrobenzo[b]furans. In analogous cyclization, products of selective reduction of a nitro group in O-(3,5-dinitrophenyl) ketoximes unexpectedly yield, along with 6-amino-4-nitrobenzofurans, 4-hydroxy-6- nitroindoles. The 4-NO2 group is displaced from 4,6-dinitrobenzo[b] furans in reactions with thiols in the presence of K2CO3. Conditions for nitration and sulfochlorination of 4,6-dinitrobenzo[b]furans in position 3 were found. Condensation of a 2-methyl derivative with dimethylformamide acetal was accomplished.
