72582-66-2

Upstream product

• 20397-61-9 (Z)-2-fluoro-3-phenylacrylic acid 

Downstream Products

• 88556-22-3 2-((Z)-2-Fluoro-3-phenyl-acryloylamino)-3-phenyl-propionic acid 
• 107131-23-7 ethyl 1-(4-hydroxyphenyl)-4-oxo-5-fluoro-6-phenyl-1,4-dihydropyridine-3-carboxylate 
• 107131-07-7 ethyl 1-(4-hydroxyphenyl)-4-oxo-5-fluoro-6-phenyl-1,4,5,6-tetrahydropyridine-3-carboxylate 
• 1247007-65-3 (Z)-5-(ethylsulfonyl)-2-(1-fluoro-2-phenylvinyl)benzo[d]oxazole 
• 116761-08-1 C₁₂H₁₄FO₂S⁽¹⁺⁾*Cl^(1-) 
• 116761-05-8 C₁₂H₁₃FO₂S 
• 116761-10-5 (3Z)-1-chloro-3-fluoro-4-phenyl-3-buten-2-one 
• 116761-00-3 (Z)-2-Fluoro-3-phenyl-acrylic acid phenyl ester 
• 116761-01-4 (Z)-tert-butyl α-fluorocinnamate 
• 88556-22-3 2-((Z)-2-Fluoro-3-phenyl-acryloylamino)-3-phenyl-propionic acid 

Relevant academic research and scientific papers

Modular Cyclopentenone Synthesis through the Catalytic Molecular Shuffling of Unsaturated Acid Chlorides and Alkynes

We describe a general strategy for the intermolecular synthesis of polysubstituted cyclopentenones using palladium catalysis. Overall, this reaction is achieved via a molecular shuffling process involving an alkyne, an α,β-unsaturated acid chloride, which serves as both the alkene and carbon monoxide source, and a hydrosilane to create three new C-C bonds. This new carbon monoxide-free pathway delivers the products with excellent yields. Furthermore, the regioselectivity is complementary to conventional methods for cyclopentenone synthesis. In addition, a set of regio- and chemodivergent reactions are presented to emphasize the synthetic potential of this novel strategy.

Enantioselective palladium(0)-catalyzed nazarov-type cyclization

A Pd0-catalyzed asymmetric Nazarov-type cyclization is described. The optimized ligand for the reaction incorporates a weakly coordinating pyridine ring into a TADDOL-derived phosphoramidite (TADDOL=α,α,α,α-tetraaryl-1,3-dioxolane-4,5-dimethanol). The reaction leads to the formation of cyclopentenones as single diastereoisomers that incorporate two contiguous asymmetric centers, one tertiary and one an all-carbon-atom quaternary stereocenter, in high yield and optical purity. It is noteworthy that the reaction does not require that substrates should be activated by aryl substituents.

Synthesis and antimicrobial activity of DNA-gyrase inhibiting derivatives of 4-oxo-1,4-dihydro-3-pyridinecarboxylic acid

A series of 6-substituted-1-aryl-4-oxo-1,4-dihydronicotinic acids were synthesised as monocyclic analogues of the quinolones. The 6-(2-aryl-1-methylethenyl)- and of the 6-(2-arylethenyl)-substituted compounds were shown to possess antibacterial properties