72586-67-5 Usage
Chemical structure
1-(p-Acetylphenyl)-3-methyl-3-nitrosourea is a synthetic chemical compound with the formula C10H11N3O3.
Function
It is commonly used in research settings as a mutagen and carcinogen.
Mechanism of action
It is a potent DNA alkylating agent, meaning it can transfer an alkyl group to nucleophilic nitrogen or oxygen atoms in DNA.
Effects on DNA
This transfer of an alkyl group can lead to mutations in the DNA sequence.
Potential health risks
The compound has the potential to cause cancer due to its mutagenic and carcinogenic properties.
Research applications
It has been extensively studied for its ability to induce tumors in experimental animals and has been used in animal models to explore the mechanisms of carcinogenesis.
Safety precautions
Due to its potential harmful effects, 1-(p-Acetylphenyl)-3-methyl-3-nitrosourea is handled with caution in laboratory and industrial settings.
Regulatory measures
Its use is regulated to minimize human and environmental exposure.
Check Digit Verification of cas no
The CAS Registry Mumber 72586-67-5 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 7,2,5,8 and 6 respectively; the second part has 2 digits, 6 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 72586-67:
(7*7)+(6*2)+(5*5)+(4*8)+(3*6)+(2*6)+(1*7)=155
155 % 10 = 5
So 72586-67-5 is a valid CAS Registry Number.
InChI:InChI=1/C10H11N3O3/c1-7(14)8-3-5-9(6-4-8)11-10(15)13(2)12-16/h3-6H,1-2H3,(H,11,15)
72586-67-5Relevant academic research and scientific papers
Yoshida, Kitaro,Yano, Kazuyuki
, p. 2200 - 2203 (1982)
The decomposition reactions of N-methyl-N'-aryl-N-nitrosoureas (1) and of N,N'-dimethyl-N'-aryl-N-nitrosoureas (2) were studied kinetically in phosphate buffer solution.All nitrosoureas 1 were easily hydrolyzed even under conditions and the rates of hydrolysis were found to be proportional to the hydroxide ion concentration over pH range 5.4-7.6.General base catalysis by buffer components was negligible. The reaction was subjected to the elimination mechanism in which an abstraction of the urcido proton was involved as an initial step.On the other hand, nitrosoureas 2 had no significant reactivity under the same conditions.
