726-79-4 Usage
General Description
2,4,6(1H,3H,5H)-Pyrimidinet, also known as trimethoprim, is a synthetic antibacterial agent that is commonly used in combination with sulfamethoxazole to treat a variety of bacterial infections. Trimethoprim works by inhibiting the enzyme dihydrofolate reductase, which is involved in the synthesis of DNA and RNA in bacteria. This disruption of folate metabolism ultimately leads to the inhibition of bacterial growth and replication. Trimethoprim is effective against a broad spectrum of bacteria, including many Gram-positive and Gram-negative strains. It is often used to treat urinary tract infections, respiratory infections, and skin and soft tissue infections. While generally well tolerated, trimethoprim can cause side effects such as nausea, vomiting, and allergic reactions in some individuals. Overall, trimethoprim is an important and widely used antibiotic in the treatment of bacterial infections.
Check Digit Verification of cas no
The CAS Registry Mumber 726-79-4 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 7,2 and 6 respectively; the second part has 2 digits, 7 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 726-79:
(5*7)+(4*2)+(3*6)+(2*7)+(1*9)=84
84 % 10 = 4
So 726-79-4 is a valid CAS Registry Number.
726-79-4Relevant articles and documents
Late-Stage Intermolecular Allylic C-H Amination
Clark, Joseph R.,Dixon, Charlie F.,Feng, Kaibo,Han, Wei,Ide, Takafumi,Koch, Vanessa,Teng, Dawei,Wendell, Chloe I.,White, M. Christina
, p. 14969 - 14975 (2021/10/01)
Allylic amination enables late-stage functionalization of natural products where allylic C-H bonds are abundant and introduction of nitrogen may alter biological profiles. Despite advances, intermolecular allylic amination remains a challenging problem due to reactivity and selectivity issues that often mandate excess substrate, furnish product mixtures, and render important classes of olefins (for example, functionalized cyclic) not viable substrates. Here we report that a sustainable manganese perchlorophthalocyanine catalyst, [MnIII(ClPc)], achieves selective, preparative intermolecular allylic C-H amination of 32 cyclic and linear compounds, including ones housing basic amines and competing sites for allylic, ethereal, and benzylic amination. Mechanistic studies support that the high selectivity of [MnIII(ClPc)] may be attributed to its electrophilic, bulky nature and stepwise amination mechanism. Late-stage amination is demonstrated on five distinct classes of natural products, generally with >20:1 site-, regio-, and diastereoselectivity.
