726-79-4 Usage
Uses
Used in Pharmaceutical Industry:
2,4,6(1H,3H,5H)-Pyrimidinet is used as an antibiotic for the treatment of various bacterial infections. It is particularly effective against urinary tract infections, respiratory infections, and skin and soft tissue infections. The combination of trimethoprim with sulfamethoxazole enhances its antibacterial activity and broadens its spectrum of action.
Used in Combination Therapy:
2,4,6(1H,3H,5H)-Pyrimidinet is used in combination with sulfamethoxazole to increase the effectiveness of treatment against bacterial infections. This combination therapy helps to overcome bacterial resistance and provides a synergistic effect, leading to better clinical outcomes.
Used in Research and Development:
Trimethoprim is also used in research and development for the study of bacterial resistance mechanisms, the development of new antibiotics, and the understanding of the role of dihydrofolate reductase in bacterial growth and replication.
While trimethoprim is generally well-tolerated, it can cause side effects such as nausea, vomiting, and allergic reactions in some individuals. However, its effectiveness and broad-spectrum action make it an important antibiotic in the treatment of bacterial infections.
Check Digit Verification of cas no
The CAS Registry Mumber 726-79-4 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 7,2 and 6 respectively; the second part has 2 digits, 7 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 726-79:
(5*7)+(4*2)+(3*6)+(2*7)+(1*9)=84
84 % 10 = 4
So 726-79-4 is a valid CAS Registry Number.
726-79-4Relevant academic research and scientific papers
Late-Stage Intermolecular Allylic C-H Amination
Clark, Joseph R.,Dixon, Charlie F.,Feng, Kaibo,Han, Wei,Ide, Takafumi,Koch, Vanessa,Teng, Dawei,Wendell, Chloe I.,White, M. Christina
, p. 14969 - 14975 (2021/10/01)
Allylic amination enables late-stage functionalization of natural products where allylic C-H bonds are abundant and introduction of nitrogen may alter biological profiles. Despite advances, intermolecular allylic amination remains a challenging problem due to reactivity and selectivity issues that often mandate excess substrate, furnish product mixtures, and render important classes of olefins (for example, functionalized cyclic) not viable substrates. Here we report that a sustainable manganese perchlorophthalocyanine catalyst, [MnIII(ClPc)], achieves selective, preparative intermolecular allylic C-H amination of 32 cyclic and linear compounds, including ones housing basic amines and competing sites for allylic, ethereal, and benzylic amination. Mechanistic studies support that the high selectivity of [MnIII(ClPc)] may be attributed to its electrophilic, bulky nature and stepwise amination mechanism. Late-stage amination is demonstrated on five distinct classes of natural products, generally with >20:1 site-, regio-, and diastereoselectivity.
