726134-79-8

Basic information

• Product Name: BENZENEPROPANOL, B,4-DIAMINO-, (S)-
• Synonyms: BENZENEPROPANOL, B,4-DIAMINO-, (S)-;(S)-2-amino-3-(4-aminophenyl)propanol
• CAS NO: 726134-79-8
• Molecular Weight: 166.223
• Mol File: 726134-79-8.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: BENZENEPROPANOL, B,4-DIAMINO-, (S)-(CAS DataBase Reference)
• NIST Chemistry Reference: BENZENEPROPANOL, B,4-DIAMINO-, (S)-(726134-79-8)
• EPA Substance Registry System: BENZENEPROPANOL, B,4-DIAMINO-, (S)-(726134-79-8)

Safety Data

• Hazardous Substances Data: 726134-79-8(Hazardous Substances Data)

Upstream product

• 89288-22-2 (S)-(-)-2-amino-3-(4-nitrophenyl)propan-1-ol 
• 114346-29-1 tert-butyl N-[(2S)-1-hydroxy-3-(4-nitrophenyl)propan-2-yl]carbamate 
• 33305-77-0 Boc-Phe(p-NO₂)-OH 

Downstream Products

• 152305-23-2 (S)-4-(4-aminobenzyl)-1,3-oxazolidin-2-one 

Relevant articles and documents

ANTIBODY DRUG CONJUGATES

This application discloses anti-P-cadherin antibodies, antigen binding fragments thereof, and antibody drug conjugates of said antibodies or antigen binding fragments, particularly antibody drug conjugates comprising anti-P-cadherin antibodies conjugated to auristatin analogs. The invention also relates to methods of treating cancer using the antibody drug conjugates. Also disclosed herein are methods of making the antibodies, antigen binding fragments, and antibody drug conjugates, and methods of using the antibodies and antigen binding fragments as diagnostic reagents.

A NOVEL AND AN IMPROVED PROCESS FOR THE PREPARATION OF (S)-4-(4-AMINOBENZYL)-2- OXAZOLIDINONE

The invention disclosed in this application relates to an improved process for the preparation of the oxazolidinone of formula (I) It comprises (i) Preparing the 4-nitro-(S)-phenylalaninol of formula (IV) by conventional methods. (ii) Reducing the nitro compound of formula (IV), (iii) Reacting the resulting novel compound of the formula (II) with dialkyl carbonate at a temperature in the range of 80-200 °C. to produce the compound of the formula I. The compound of the formula I is useful for the preparation of zolmitriptan which is an important drug for the treatment of migraine.