726144-38-3Relevant academic research and scientific papers
Novel Allosteric Activators for Ferroptosis Regulator Glutathione Peroxidase 4
Li, Cong,Deng, Xiaobing,Zhang, Weilin,Xie, Xiaowen,Conrad, Marcus,Liu, Ying,Angeli, José Pedro Friedmann,Lai, Luhua
, p. 266 - 275 (2019/01/15)
Glutathione peroxidase 4 (GPX4) is essential for cell membrane repair, inflammation suppression, and ferroptosis inhibition. GPX4 upregulation provides unique drug discovery opportunities for inflammation and ferroptosis-related diseases. However, rationa
Synthesis and SAR of selective small molecule neuropeptide y Y2 receptor antagonists
Mittapalli, Gopi Kumar,Vellucci, Danielle,Yang, Jun,Toussaint, Marion,Brothers, Shaun P.,Wahlestedt, Claes,Roberts, Edward
scheme or table, p. 3916 - 3920 (2012/07/03)
Highly potent and selective small molecule neuropeptide Y Y2 receptor antagonists are reported. The systematic SAR exploration of a hit molecule N-(4-ethoxyphenyl)-4-[hydroxy(diphenyl)methyl]piperidine-1-carbothioamide, identified from HTS, led to the discovery of highly potent NPY Y2 antagonists 16 (CYM 9484) and 54 (CYM 9552) with IC50 values of 19 nM and 12 nM respectively.
