726185-65-5

Upstream product

• 14295-52-4 4-(diethyoxyphosphorylmethyl)benzoic acid methyl ester 
• 79099-07-3 N-tert-butyloxycarbonylpiperidin-4-one 
• 2417-72-3 Methyl 4-(bromomethyl)benzoate 
• 85838-94-4 N-Boc-1,2,3,6-tetrahydropyridine 
• 159635-49-1 tert-butyl 4-methylidenepiperidine-1-carboxylate 
• 5798-75-4 Ethyl 4-bromobenzoate 

Downstream Products

• 726185-64-4 tert-butyl 4-[(4-ethoxycarbonylphenyl)methyl]piperidine-1-carboxylate 
• 1425970-70-2 tert-butyl 4-(4-(hydroxymethyl)benzylidene)piperidine-1-carboxylate 
• 1425970-71-3 tert-butyl 4-(4-(bromomethyl)benzylidene)piperidine-1-carboxylate 
• 1425970-72-4 tert-butyl 4-{4-[(2-oxopyridin-1(2H)-yl)methyl]benzylidene}piperidine-1-carboxylate 
• 1425970-78-0 tert-butyl 4-{4-[(3-methoxy-2-oxopyridin-1(2H)-yl)methyl]benzylidene}piperidine-1-carboxylate 
• 1425970-96-2 tert-butyl 4-(4-{[(4R)-4-{[tert-butyl(dimethyl)silyl]oxy}-2-oxopyrrolidine-1-yl]methyl}benzylidene)piperidine-1-carboxylate 
• 1425970-99-5 tert-butyl 4-{4-[(3-methyl-2-oxoimidazolidin-1-yl)methyl]benzylidene}piperidine-1-carboxylate 
• 1425971-11-4 tert-butyl 4-[4-({[1-methyl-3-(trifluoromethyl)-1H-pyrazol-5-yl]oxy}methyl)benzylidene]piperidine-1-carboxylate 
• 1425971-17-0 tert-butyl 4-[4-(piperidin-1-ylmethyl)benzylidene]piperidine-1-carboxylate 
• 1425972-67-3 tert-butyl 4-bromo-4-{bromo[4-(ethoxycarbonyl)phenyl]methyl}piperidine-1-carboxylate 
• 1425972-68-4 tert-butyl 4-{bromo[4-(ethoxycarbonyl)phenyl]methylidene}piperidine-1-carboxylate 

Relevant academic research and scientific papers

TRICYCLIC DEGRADERS OF IKAROS AND AIOLOS

Tricyclic cereblon binders for the degradation of Ikaros or Aiolos by the ubiquitin proteasome pathway for therapeutic applications are described.

MULTI-RING COMPOUNDS AND USES THEREOF

Chemical agents, such as derivatives of hydroxy benzene moieties, and similar heterocyclic ring structures, including salts thereof, that act as anti-cancer and anti-tumor agents, especially where such agents modulate the activity of enzymes and structura

Discovery of a piperidine-4-carboxamide CCR5 antagonist (TAK-220) with highly potent anti-HIV-1 activity

We incorporated various polar groups into previously described piperidine-4-carboxamide CCR5 antagonists to improve their metabolic stability in human hepatic microsomes. Introducing a carbamoyl group into the phenyl ring of the 4-benzylpiperidine moiety

Carboxylic acids and the esters thereof, pharmaceutical compositions thereto and processes for the preparation thereof

The present invention relates to carboxylic acids and esters of general formula wherein Ar, R, R1, X1, X3, X4, Y and Y1 are defined as in claim 1, the tautomers, the diastereomers, the enantiomers, the mixtures thereof and the salts thereof, particularly the physiologically acceptable salts thereof with inorganic or organic acids or bases, pharmaceutical compositions containing these compounds, the use thereof and processes for the preparation thereof, as well as the use thereof for the production and purification of antibodies and as labelled compounds in RIA and ELISA assays and as diagnostic or analytical aids in neurotransmitter research.