72634-82-3Relevant academic research and scientific papers
Discovery of novel motilin antagonists: Conversion of tetrapeptide leads to orally available peptidomimetics
Taka, Naoki,Matsuoka, Hiroharu,Sato, Tsutomu,Yoshino, Hitoshi,Imaoka, Ikuhiro,Sato, Haruhiko,Kotake, Ken-ichiro,Kumagai, Yoshikazu,Kamei, Kenshi,Ozaki, Ken-ichi,Higashida, Atsuko,Kuroki, Toshio
scheme or table, p. 3426 - 3429 (2010/02/28)
We successfully discovered peptidomimetic motilin antagonists (17c and 17d) through the improvement of physicochemical properties of a tetrapeptide antagonist (2). Furthermore, with oral administration and based on motilin antagonistic activity, both comp
