72646-01-6Relevant academic research and scientific papers
One-pot synthesis of n-aryl-nicotinamides and diarylamines based on a tunable smiles rearrangement
Liu, Shihui,Zhu, Shaofan,Wu, Ying,Gao, Jiayu,Qian, Pengfei,Hu, Yanwei,Shi, Linsen,Chen, Shaohua,Zhang, Shilei,Zhang, Yinan
supporting information, p. 3048 - 3052 (2015/05/13)
A one-pot Smiles rearrangement has been developed as a useful protocol for the straightforward synthesis of diverse N-aryl-nicotinamides. This method also provides chemoselective access toward diarylamines based on the different substitutions of the amide group. The potential application of the transformation is exemplified by the synthesis of an on-market succinate dehydrogenase inhibitor, boscalid. A substituent-mediated Smiles rearrangement to N-aryl-nicotinamides and diarylamines has been developed. In addition to the wide range of heterocyclic building blocks, the one-pot process also provides an efficient access to an on-market fungicide, boscalid.
Design of novel N-phenylnicotinamides as selective cyclooxygenase-1 inhibitors
Shi, Lei,Li, Zi-Lin,Yang, Ying,Zhu, Zhen-Wei,Zhu, Hai-Liang
supporting information; experimental part, p. 121 - 124 (2011/02/25)
A series of N-phenylnicotinamides (1-40) were designed and evaluated in vitro for their COX inhibitory activities. Most of the synthesized compounds were proved to be potent and selective inhibitors of COX-1. Compound 28 showed the most potent COX-1 inhib
