72651-98-0

Basic information

• Product Name: 2,2-DIMETHYL-5-(3-INDOLYLMETHYL)-1,3-DIOXANE-4,6-DIONE
• Synonyms: 2,2-DIMETHYL-5-(3-INDOLYLMETHYL)-1,3-DIOXANE-4,6-DIONE
• CAS NO: 72651-98-0
• Molecular Formula: C₁₅H₁₅NO₄
• Molecular Weight: 0
• Mol File: 72651-98-0.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 569.8°C at 760 mmHg
• Flash Point: 298.4°C
• Appearance: /
• Density: 1.297g/cm³
• Vapor Pressure: 5.34E-13mmHg at 25°C
• Refractive Index: 1.606
• CAS DataBase Reference: 2,2-DIMETHYL-5-(3-INDOLYLMETHYL)-1,3-DIOXANE-4,6-DIONE(CAS DataBase Reference)
• NIST Chemistry Reference: 2,2-DIMETHYL-5-(3-INDOLYLMETHYL)-1,3-DIOXANE-4,6-DIONE(72651-98-0)
• EPA Substance Registry System: 2,2-DIMETHYL-5-(3-INDOLYLMETHYL)-1,3-DIOXANE-4,6-DIONE(72651-98-0)

Safety Data

• Hazardous Substances Data: 72651-98-0(Hazardous Substances Data)

Usage

General Description

2,2-DIMETHYL-5-(3-INDOLYLMETHYL)-1,3-DIOXANE-4,6-DIONE is a chemical compound with a complex and unique structure. It contains two methyl groups and an indolylmethyl group attached to a dioxane-4,6-dione ring system. 2,2-DIMETHYL-5-(3-INDOLYLMETHYL)-1,3-DIOXANE-4,6-DIONE may have potential applications in the pharmaceutical or chemical industries due to its distinctive structure and potential reactivity. Further research and analysis would be needed to fully understand the properties and potential uses of this complex chemical compound.

InChI:InChI=1/C15H15NO4/c1-15(2)19-13(17)11(14(18)20-15)7-9-8-16-12-6-4-3-5-10(9)12/h3-6,8,11,16H,7H2,1-2H3

Upstream product

• 68588-31-8 5-[(1H-indol-3-yl)methylidene]-2,2-dimethyl-1,3-dioxane-4,6-dione 
• 120-72-9 indole 
• 2033-24-1 cycl-isopropylidene malonate 
• 50-00-0 formaldehyd 
• 152125-90-1 1-<(6-hydroxy-2,2-dimethyl-4-oxo-4H-1,3-dioxin-5-yl)methyl>pyridinium hydroxide 

Downstream Products

• 133040-63-8 3-(3-Chloro-phenyl)-2-[2-(1H-indol-3-yl)-ethyl]-3H-quinazolin-4-one 
• 133040-60-5 2-[2-(1H-Indol-3-yl)-ethyl]-3-(2-methoxy-phenyl)-3H-quinazolin-4-one 
• 133040-57-0 2-[2-(3-indolyl)ethyl]-3-phenyl-4-(3H)quinazolinone 
• 133040-61-6 2-[2-(1H-Indol-3-yl)-ethyl]-3-(2-trifluoromethyl-phenyl)-3H-quinazolin-4-one 
• 133040-68-3 LY 247348 
• 133040-62-7 3-(3-Fluoro-phenyl)-2-[2-(1H-indol-3-yl)-ethyl]-3H-quinazolin-4-one 
• 133040-66-1 3-(3-Ethyl-phenyl)-2-[2-(1H-indol-3-yl)-ethyl]-3H-quinazolin-4-one 
• 133040-69-4 2-[2-(1H-Indol-3-yl)-ethyl]-3-(3-trifluoromethyl-phenyl)-3H-quinazolin-4-one 
• 133040-59-2 3-(2-Chloro-phenyl)-2-[2-(1H-indol-3-yl)-ethyl]-3H-quinazolin-4-one 
• 133040-67-2 2-[2-(1H-Indol-3-yl)-ethyl]-3-(3-methoxy-phenyl)-3H-quinazolin-4-one 
• 133040-58-1 3-(2-Fluoro-phenyl)-2-[2-(1H-indol-3-yl)-ethyl]-3H-quinazolin-4-one 
• 133040-64-9 3-(3-Bromo-phenyl)-2-[2-(1H-indol-3-yl)-ethyl]-3H-quinazolin-4-one 
• 133040-65-0 2-[2-(1H-Indol-3-yl)-ethyl]-3-m-tolyl-3H-quinazolin-4-one 

Relevant articles and documents

Trimolecular condensation of substituted indoles with paraformaldehyde and Meldrum's acid. Convective heating versus microwave irradiation: A comparative study

Results obtained in a comparative study on the trimolecular condensation of substituted indoles 1 with paraformaldehyde and Meldrum's acid using convective heating vs. microwave irradiation are described. Both methods afforded adducts 2 together with their hydroxymethylated derivatives 3 in good yields. Although in both cases the yields are about the same, the microwave irradiation was found to be more advantageous, as this procedure makes possible to considerably reduce the reaction times and to obtain cleaner reaction mixtures.

Synthesis of 5-[(indol-2-on-3-yl)methyl]-2,2-dimethyl-1,3-dioxane-4,6- diones and spirocyclopropyloxindole derivatives. Potential aldose reductase inhibitors

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Borohydride reduction of substituted isopropylidene methylenemalonates

Knoevenagel-type products derived from Meldrum's Acid are readily reduced by sodium borohydride to give monosubstituted isopropylidene malonates in high yield.