72669-53-5

Basic information

• Product Name: H-GLU(AMC)-OH
• Synonyms: (S)-2-AMINO-5-(7-AMIDO-4-METHYL COUMARIN)-5-OXOPENTANOIC ACID;GLUTAMIC ACID(AMC)-OH;GAMMA-L-GLUTAMIC ACID 7-AMIDO-4-METHYLCOUMARIN;GAMMA-L-GLUTAMIC ACID-AMC;G-L-GLUTAMIC ACID 7-AMIDO-4-METHYLCOUMARIN;L-GLUTAMIC ACID GAMMA-(7-AMIDO-4-METHYLCOUMARIN);H-GLU(AMC)-OH;7-(gamma-glutamyl)-4-methylcoumarylamide
• CAS NO: 72669-53-5
• Molecular Formula: C₁₅H₁₆N₂O₅
• Molecular Weight: 304.3
• Product Categories: Other enzyme inhibitors and activators;substrate
• Mol File: 72669-53-5.mol

Chemical Properties

• Boiling Point: 624.9 °C at 760 mmHg
• Flash Point: 331.7 °C
• Appearance: White to Off-white/Powder
• Density: 1.406 g/cm³
• Vapor Pressure: 1.89E-20mmHg at 25°C
• Refractive Index: 1.637
• Storage Temp.: −20°C
• CAS DataBase Reference: H-GLU(AMC)-OH(CAS DataBase Reference)
• NIST Chemistry Reference: H-GLU(AMC)-OH(72669-53-5)
• EPA Substance Registry System: H-GLU(AMC)-OH(72669-53-5)

Safety Data

• Safety Statements: 24/25
• WGK Germany: 3
• Hazardous Substances Data: 72669-53-5(Hazardous Substances Data)

Usage

Uses

H-GLU(AMC)-OH is used as a fluorogenic substrate for the detection and quantification of enzyme activity in various applications.
Used in Biochemical Assays:
H-GLU(AMC)-OH is used as a substrate for aminopeptidase A or the assay of gamma-glutamyl transferase (GGT) for the detection of enzyme activity. The cleavage of the peptide bond by these enzymes releases the AMC moiety, which exhibits blue fluorescence, allowing for the measurement of enzyme activity in a sensitive and quantitative manner.
Used in Pharmaceutical Research:
H-GLU(AMC)-OH is used as a research tool in the development of new drugs targeting enzymes involved in various diseases. By monitoring the activity of these enzymes using H-GLU(AMC)-OH, researchers can evaluate the efficacy of potential drug candidates and optimize their chemical structures for better therapeutic outcomes.
Used in Quality Control:
H-GLU(AMC)-OH is used in the quality control of pharmaceutical products, ensuring that the enzymes of interest are present and active at the desired levels. This helps maintain the safety and efficacy of the products, as well as ensuring compliance with regulatory standards.
Used in Diagnostics:
H-GLU(AMC)-OH can be employed in the development of diagnostic tests for various conditions, particularly those involving the dysregulation of enzyme activity. By measuring the activity of specific enzymes using H-GLU(AMC)-OH, healthcare professionals can gain valuable insights into the underlying causes of a patient's symptoms and develop appropriate treatment plans.

InChI:InChI=1/C15H16N2O5/c1-8-6-14(19)22-12-7-9(2-3-10(8)12)17-11(15(20)21)4-5-13(16)18/h2-3,6-7,11,17H,4-5H2,1H3,(H2,16,18)(H,20,21)/t11-/m0/s1

Upstream product

• 75957-52-7 7-(N^α-benzyloxycarbonyl-α-benzyl-γ-L-glutaminyl)-4-methylcoumarinylamide 
• 26093-31-2 7-amino-4-methylcoumarin. 
• 3705-42-8 Cbz-(L)-Glu-OBn 
• 7159-96-8 ethyl N-(3-hydroxyphenyl)carbamate 
• 58632-48-7 (4-methyl-2-oxo-2H-1-benzopyran-7-yl)carbamic acid ethyl ester 

Downstream Products

• 26093-31-2 7-amino-4-methylcoumarin.