72678-02-5

Basic information

• Product Name: 1-methoxyisoquinolin-5-amine
• Synonyms: 1-methoxyisoquinolin-5-amine
• CAS NO: 72678-02-5
• Molecular Formula: C₁₀H₁₀N₂O
• Molecular Weight: 174.1992
• Mol File: 72678-02-5.mol
• Article Data: 2

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1-methoxyisoquinolin-5-amine(CAS DataBase Reference)
• NIST Chemistry Reference: 1-methoxyisoquinolin-5-amine(72678-02-5)
• EPA Substance Registry System: 1-methoxyisoquinolin-5-amine(72678-02-5)

Safety Data

• Hazardous Substances Data: 72678-02-5(Hazardous Substances Data)

Usage

Classification

An amine derivative of isoquinoline.

Origin

Isoquinoline is a naturally occurring compound found in many plant species.

Medicinal properties

Potential to inhibit the growth of certain cancer cells.

Synthesis applications

Investigated as a precursor in the synthesis of organic compounds.

Relevance

A subject of interest in various fields of research, including medicinal chemistry and organic synthesis.

Versatility

Potential applications in both medicinal and synthetic chemistry.

Upstream product

• 72678-03-6 1-Methoxy-5-nitroisoquinoline 
• 58142-97-5 1-chloro-5-nitroisoquinoline 
• 19493-44-8 1-chloroisoquinoline 
• 491-30-5 1-hydroxyisoquinoline 

Downstream Products

• 369652-59-5 2-(1-methoxy-5-isoquinolineamino)-3-nitrobenzoic acid 

Relevant articles and documents

Structure-activity relationships for pyrido-, imidazo-, pyrazolo-, pyrazino-, and pyrrolophenazinecarboxamides as topoisomerase-targeted anticancer agents

Heterocyclic phenazinecarboxamides were prepared by condensation of aminoheterocycles and 2-halo-3-nitrobenzoic acids, followed by reductive ring closure and amidation. They showed similar inhibition of paired cell lines that underexpressed topo II or overexpressed P-glycoprotein, indicating a non topo II mechanism of cytotoxicity and indifference to P-glycoprotein mediated multidrug resistance. Compounds with a fused five-membered heterocyclic ring were generally less potent than the pyrido[4,3-a]phenazines. A 4-methoxypyrido[4,3-a]phenazine (IC50s 2.5-26 nM) gave modest (ca. 5 day) growth delays in H69/P xenografts with oral dosing.