72684-95-8

Usage

Uses

Used in Polymer Synthesis:
4-Cyano-2,6-dimethoxyphenol is used as a reactant in the switching and extension of daisy-chain dimer polymer. Its unique structure allows for the formation of novel polymers with specific properties, making it a valuable component in the development of advanced materials for various applications.
If there are additional applications in different industries, they can be listed as follows:
Used in Pharmaceutical Industry:
4-Cyano-2,6-dimethoxyphenol can be used as an intermediate in the synthesis of various pharmaceutical compounds due to its reactive functional groups. Its ability to form covalent bonds with other molecules makes it a promising candidate for the development of new drugs with specific therapeutic properties.
Used in Chemical Synthesis:
In the field of chemical synthesis, 4-Cyano-2,6-dimethoxyphenol can be employed as a building block for the creation of a wide range of organic compounds. Its versatility in reacting with various reagents opens up possibilities for the synthesis of novel molecules with potential applications in different industries, such as agriculture, materials science, and environmental science.
Used in Dye and Pigment Industry:
The unique structure of 4-Cyano-2,6-dimethoxyphenol may also find applications in the dye and pigment industry. Its ability to form stable complexes with other molecules can lead to the development of new dyes and pigments with improved color properties and stability.

InChI:InChI=1/C9H9NO3/c1-12-7-3-6(5-10)4-8(13-2)9(7)11/h3-4,11H,1-2H3

Upstream product

• 54738-29-3 4-acetoxy-3,5-dimethoxy-benzonitrile 
• 19179-31-8 3,5-dimethoxy-benzonitrile 
• 1885-35-4 3,4,5-trimethoxybenzonitrile 
• 134-96-3 syringic aldehyde 
• 123-08-0 4-hydroxy-benzaldehyde 
• 2973-77-5 3,5-dibromo-4-hydroxybenzaldehyde 

Downstream Products

• 95065-45-5 4-carbamimidoyl-2,6-dimethoxyphenol 
• 95065-30-8 Benzoic acid 4-carbamimidoyl-2,6-dimethoxy-phenyl ester 
• 1188547-68-3 C₂₀H₂₉NO₅ 
• 1239861-00-7 4-(2-chloroquinazolin-4-yloxy)-3,5-dimethoxybenzonitrile 
• 1357621-03-4 1,5-bis(4-cyano-2,6-dimethoxyphenoxy)-N-methyl-3-azapentane 
• 1357621-15-8 N,N-bis[2-(4-cyano-2,6-dimethoxyphenoxy)ethyl]benzenesulfonamide 
• 1319736-47-4 3,5-dimethoxy-4-(2-morpholine-4-yl-ethoxy)benzonitrile 
• 1319736-48-5 3,5-dimethoxy-4-(4-tetrahydropyranyloxy)benzonitrile 
• 1188547-54-7 C₅₃H₇₃NO₁₁*ClH 
• 1188547-53-6 C₅₈H₈₁NO₁₂ 
• 1188547-50-3 C₅₈H₇₉NO₁₂ 
• 1188547-52-5 C₂₀H₃₃NO₅ 

Relevant academic research and scientific papers

SMALL MOLECULE NEUTRAL SPHINGOMYELINASE 2 (NSMASE2) INHIBITORS

Small molecule inhibitors of neutral sphingomyelinase 2 (nSMase2) and their use for treating neurodegenerative diseases, such as, neurodegenerative diseases associated with high levels of ceramide, including, but not limited to Alzheimer's disease (AD), H

Direct synthesis of nitriles from aldehydes with hydroxylamine-O-sulfonic acid in acidic water

Herein is reported the selective transformation of aldehydes to nitriles in the presence of hydroxylamine-O-sulfonic acid (NH2OSO3H) as a source of the N atom and acidic water. The reaction works with high yields for a large array of aromatic and aliphatic aldehydes, as well as hindered aldehydes and conjugated aldehydes without purification. The reaction conditions are very mild and tolerate a wide array of functional groups. In principle, the reaction can be completed in vinegar.

Utility of Nitrogen Extrusion of Azido Complexes for the Synthesis of Nitriles, Benzoxazoles, and Benzisoxazoles

The utility of the nitrogen extrusion reaction of azido complexes, generated in situ from the corresponding aldehydes or ketones with TMSN3 in the presence of ZrCl4 or TfOH, has been described. These azido complexes could undergo three different pathways, depending on the substrates. First, azido methanolate complexes or imine diazonium ions could lead to benzisoxazole products via an intramolecular nucleophilic substitution. Second, imine diazonium ions could also undergo either the elimination of proton to provide nitrile products in good to excellent yields or an aryl migration, followed by an intramolecular nucleophilic addition, to give benzoxazole products in good yields.

Chemoselective Schmidt reaction mediated by triflic acid: Selective synthesis of nitriles from aldehydes

An excellent utility of Schmidt reaction of aldehydes to access corresponding nitriles in an instantaneous reaction is demonstrated. The reaction of aldehydes with NaN3 and TfOH furnishes the corresponding nitriles in near quantitative yields and tolerates a variety of electron-withdrawing and electron-donating substituents on the substrates. Formanilides, a common side product in Schmidt reaction, is not observed in this reaction. Besides these advantages, the salient feature of this reaction is that it exhibits a remarkable chemoselectivity, as acid and ketone functionalities are well tolerated under the reaction conditions. The reaction is easily scalable, high yielding, and nearly instantaneous.

SUBSTITUTED NAPHTHYRIDINES AND THEIR USE AS MEDICAMENTS

The invention relates to new substituted naphthyridines of formula 1, as well as pharmacologically acceptable salts, diastereomers, enantiomers, racemates, hydrates or solvates thereof, wherein R1 is selected from among —O—R3 or —NR3R4,R3 is C1-6-alkyl which is substituted by R5 and R6,R5 is selected from hydrogen, branched or linear C1-6-alkyl, C2-6-alkenyl, —C1-6-alkylen-O—C1-3-alkyl, C1-3-haloalkyl,R6 is ring X wherein n is either 0 or 1, and is a either a single or a double bond andwherein A, B, D and E are each independently from one another selected from CH2, CH, C, N, NH, O or S and wherein ring X is attached to the molecule either via position A, B, D or E, wherein said ring X may optionally be further substituted by one, two or three residues each selected individually from the group consisting of -oxo, hydroxy, —C1-3-alkyl, —C1-3-haloalkyl, —O—C1-3-alkyl, —C1-3-alkanol and halogen,and wherein R4, R2, R7, R8, R9, R10, R11 and Q may have the meanings as given in claim 1, as well as pharmaceutical compositions containing these compounds.

SUBSTITUTED NAPHTHYRIDINES AND THEIR USE AS SYK KINASE INHIBITORS

The invention relates to new substituted naphthyridines of formula (1), as well as pharmacologically acceptable salts, diastereomers, enantiomers, racemates, hydrates or solvates thereof, wherein R1 is selected from among -O-R3 or -NR3R4, R3 is C1-6-alkyl which is substituted by R5 and R6 R5 is selected from hydrogen, branched or linear C1-6-alkyl, C2-6-alkenyl, -C1-6-alkylen-O-C1-3-alkyl, C1-3-haloalkyl, R6 is ring X wherein n is either 0 or 1, and Formula (I) is a either a single or a double bond and wherein A, B, D and E are each independently from one another selected from CH2, CH, C, N, NH, O or S and wherein ring X is attached to the molecule either via position A, B, D or E, wherein said ring X may optionally be further substituted by one, two or three residues each selected individually from the group consisting of -oxo, hydroxy, -C1-3-alkyl, -C1-3-haloalkyl, -O-C1-3-alkyl, -C1-3-alkanol and halogen, and wherein R4, R2, R7, R8, R9, R10, R11 and Q may have the meanings as given in claim 1, as well as pharmaceutical compositions containing these compounds.

INTERLOCKED MOLECULES AND RELATED COMPONENTS, COMPOSITIONS, MATERIALS, METHODS AND SYSTEMS

[c2] daisy chain macromers, dimers and polymers and related compositions, materials, methods and systems are described.

PROCESS FOR DEMETHYLATING AROMATIC METHYL ETHERS USING 3 -MERCAPTOPROPIONIC ACID

The present application discloses a process for demethylating aromatic methyl ethers by reaction with 3 -mercaptopropionic acid or salts thereof. One preferred example is the demethylation of venlafaxine forming 0 - desmethylvenlafaxine.

Process for demethylating aromatic methyl ethers using 3-mercaptopropionic acid

The present application discloses a process for demethylating aromatic methyl ethers by reaction with 3-mercaptopropionic acid or salts thereof. One preferred example is the demethylation of venlafaxine forming O-desmethylvenlafaxine.

Comparison of structure in solid state of new 1,5-bis(4-cyano-2,6-dimethoxyphenoxy)alkanes by means of 13C CP/MAS NMR and X-ray diffraction

The synthesis and structural studies in solid state of new 1,5-bis(4-cyano-2,6-dimethoxyphenoxy)-3-oxapentane 1 and 1,5-bis(4-cyano-2,6-methoxyphenoxy)pentane 2 are presented. The observed complicated network of intermolecular interaction with participation of nitrile groups could play a role in their interaction with the biological target. In vitro screen against 60 human tumor cell lines revealed that compound 1 has promising growth inhibitory power GI50 against SR (leukemia) and HOP-92 (non-small lung cancer) equal to 4.33×10-6 and 1.03×10-5 M, respectively.