7269-95-6

Basic information

• Product Name: 2,4(1H,3H)-Pyrimidinedione, 3-methyl-6-(phenylamino)-
• CAS NO: 7269-95-6
• Molecular Formula: C11H11N3O2
• Molecular Weight: 217.227
• Mol File: 7269-95-6.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 2,4(1H,3H)-Pyrimidinedione, 3-methyl-6-(phenylamino)-(CAS DataBase Reference)
• NIST Chemistry Reference: 2,4(1H,3H)-Pyrimidinedione, 3-methyl-6-(phenylamino)-(7269-95-6)
• EPA Substance Registry System: 2,4(1H,3H)-Pyrimidinedione, 3-methyl-6-(phenylamino)-(7269-95-6)

Safety Data

• Hazardous Substances Data: 7269-95-6(Hazardous Substances Data)

Usage

General Description

2,4(1H,3H)-Pyrimidinedione, 3-methyl-6-(phenylamino)- is a chemical compound with the molecular formula C11H10N4O2. It is also known by the chemical name Sunitinib, which is a medication used in the treatment of certain types of cancer, including kidney cancer and gastrointestinal stromal tumors. Sunitinib works by inhibiting the growth of cancer cells and blocking the formation of new blood vessels that can feed tumors. It is typically administered orally in the form of a capsule and is classified as a multitargeted receptor tyrosine kinase inhibitor. Along with its anticancer properties, Sunitinib also has some potential for off-label use in treating other medical conditions, such as rheumatoid arthritis and diabetic neuropathy.

Upstream product

• 4318-56-3 3-methyl-6-chlorouracil 
• 62-53-3 aniline 

Downstream Products

• 76902-97-1 3-methyl-8-chloro-10-phenyl-5-deazaisoalloxazine 
• 1079130-00-9 C₃₉H₅₁N₃O₂ 
• 144486-40-8 3,6-Dimethyl-9-phenyl-9,10-dihydro-1H,8H-1,3,6,8,9-pentaaza-anthracene-2,4,5,7-tetraone 
• 76896-53-2 8-Methoxy-3-methyl-10-phenyl-10H-pyrimido[4,5-b]quinoline-2,4-dione 
• 76896-55-4 7-Methoxy-3-methyl-10-phenyl-10H-pyrimido[4,5-b]quinoline-2,4-dione 
• 76896-56-5 7-chloro-3-methyl-10-phenyl-5-deazaflavin 
• 76896-52-1 3,7-dimethyl-9-phenyl-2,3,4,9-tetrahydro-1,3,9-triaza-anthracene-2,4-dione 
• 76896-54-3 3,7-Dimethyl-10-phenyl-10H-pyrimido[4,5-b]quinoline-2,4-dione 
• 76896-57-6 3-Methyl-5-phenyl-1H-pyrimido[4,5-b]quinoline-2,4-dione 
• 69083-37-0 3-methyl-10-phenyl-2H,3H,4H,10H-pyrimido[4,5-b] quinoline-2,4-dione 
• 92978-42-2 6-benzoyl-1,2,3,4,7,8,-hexahydro-3-methyl-8-phenyl-2,4,7-trioxopyrido<2,3-d>pyrimidine 
• 92978-41-1 6-acetyl-1,2,3,4,7,8-hexahydro-3-methyl-8-phenyl-2,4,7-triovopyrido<2,3-d>pyrimidine 
• 85103-26-0 3-Methyl-2,4-dioxo-7,8-diphenyl-2,3,4,8-tetrahydro-pyrido[2,3-d]pyrimidine-6-carboxylic acid 
• 85103-25-9 3,7-Dimethyl-2,4-dioxo-8-phenyl-2,3,4,8-tetrahydro-pyrido[2,3-d]pyrimidine-6-carboxylic acid 

Relevant articles and documents

Synthesis, biological active molecular design, and molecular docking study of novel deazaflavin-cholestane hybrid compounds

Novel deazaflavin-cholestane hybrid compounds, 3′,8′-disubstituted-5′-deazacholest-2,4-dieno[2,3-g]pteridine-2′,4′(3′H,8′H)-diones, have been synthesized by condensation reaction between 6-(monosubstituted amino)-pyrimidin-2,4(1H,3H)-diones and 2-hydroxymethylenecholest-4-en-3-one in presence of p-toluenesulfonic acid monohydrate and diphenyl ether. The antitumor activities against human tumor cell lines (CCRF-HSB-2 and KB cells) have been investigated in vitro, and many of these compounds showed promising antitumor activities. Furthermore, molecular docking study using LigandFit within the software package Discovery Studio 1.7 was done for lead optimization of these compounds as potential PTK inhibitors. In general, all of the synthesized steroid-hybrid compounds showed good binding affinities into PTK (PDB code: 1t46).

Flavins as potential antimalarials. 2. 3-Methyl-10-(substituted-phenyl)flavins

A series of 3-methyl-10-(substituted-phenyl)flavins was prepared and tested for antimalarial activity against the lethal parasite Plasmodium vinckei in mice. Several of these analogues were found to be effective antimalarial agents. A quantitative structure-activity relationship study was undertaken with 44 analogues and no satisfactory relationship could be established.