7269-95-6

Usage

Uses

Used in Oncology:
2,4(1H,3H)-Pyrimidinedione, 3-methyl-6-(phenylamino)is used as an anticancer agent for the treatment of kidney cancer and gastrointestinal stromal tumors. It works by inhibiting the growth of cancer cells and blocking the formation of new blood vessels that can feed tumors, thereby reducing tumor growth and progression.
Used in Rheumatology:
Sunitinib has potential off-label use in the treatment of rheumatoid arthritis. It may help to reduce inflammation and alleviate symptoms associated with the condition.
Used in Neurology:
Sunitinib also has potential off-label use in the treatment of diabetic neuropathy. It may help to alleviate pain and improve nerve function in patients with this condition.

Upstream product

• 4318-56-3 3-methyl-6-chlorouracil 
• 62-53-3 aniline 

Downstream Products

• 76896-46-3 C₃₀H₂₈N₆O₅ 
• 76902-97-1 3-methyl-8-chloro-10-phenyl-5-deazaisoalloxazine 
• 1079130-00-9 C₃₉H₅₁N₃O₂ 
• 144486-40-8 3,6-Dimethyl-9-phenyl-9,10-dihydro-1H,8H-1,3,6,8,9-pentaaza-anthracene-2,4,5,7-tetraone 
• 76896-53-2 8-Methoxy-3-methyl-10-phenyl-10H-pyrimido[4,5-b]quinoline-2,4-dione 
• 76896-55-4 7-Methoxy-3-methyl-10-phenyl-10H-pyrimido[4,5-b]quinoline-2,4-dione 
• 76896-56-5 7-chloro-3-methyl-10-phenyl-5-deazaflavin 
• 76896-52-1 3,7-dimethyl-9-phenyl-2,3,4,9-tetrahydro-1,3,9-triaza-anthracene-2,4-dione 
• 76896-54-3 3,7-Dimethyl-10-phenyl-10H-pyrimido[4,5-b]quinoline-2,4-dione 
• 76896-57-6 3-Methyl-5-phenyl-1H-pyrimido[4,5-b]quinoline-2,4-dione 
• 69083-37-0 3-methyl-10-phenyl-2H,3H,4H,10H-pyrimido[4,5-b] quinoline-2,4-dione 
• 92978-42-2 6-benzoyl-1,2,3,4,7,8,-hexahydro-3-methyl-8-phenyl-2,4,7-trioxopyrido<2,3-d>pyrimidine 
• 92978-41-1 6-acetyl-1,2,3,4,7,8-hexahydro-3-methyl-8-phenyl-2,4,7-triovopyrido<2,3-d>pyrimidine 
• 85103-26-0 3-Methyl-2,4-dioxo-7,8-diphenyl-2,3,4,8-tetrahydro-pyrido[2,3-d]pyrimidine-6-carboxylic acid 

Relevant academic research and scientific papers

Synthesis, biological active molecular design, and molecular docking study of novel deazaflavin-cholestane hybrid compounds

Novel deazaflavin-cholestane hybrid compounds, 3′,8′-disubstituted-5′-deazacholest-2,4-dieno[2,3-g]pteridine-2′,4′(3′H,8′H)-diones, have been synthesized by condensation reaction between 6-(monosubstituted amino)-pyrimidin-2,4(1H,3H)-diones and 2-hydroxymethylenecholest-4-en-3-one in presence of p-toluenesulfonic acid monohydrate and diphenyl ether. The antitumor activities against human tumor cell lines (CCRF-HSB-2 and KB cells) have been investigated in vitro, and many of these compounds showed promising antitumor activities. Furthermore, molecular docking study using LigandFit within the software package Discovery Studio 1.7 was done for lead optimization of these compounds as potential PTK inhibitors. In general, all of the synthesized steroid-hybrid compounds showed good binding affinities into PTK (PDB code: 1t46).

Autorecycling Oxidation of Alcohols Catalysed by Pyridopyrimidines as an NAD(P)(1+) Model

Two kinds of pyridopyrimidines as new NAD-type redox catalysts, 3,7,10-trisubstituted pyridodipyrimidine-2,4,6,8(1H,3H,7H,10H)-tetraones 6 and 3,8,10-trisubstituted pyridodipyrimidine-2,4,6(3H,7H,10H)-triones 7, have been synthesized by the condensation of 6-(substituted-amino)uracils 9 and 6-(substituted-amino)-2-phenylpyrimidin-4(3H)-ones 11 with appropriate 6-chloro-5-formyluracils 12 or 2,4,6-trichloropyrimidine-5-carbaldehyde 13 in dimethylformamide (DMF) or acetic acid.Compounds 6 and 7 have been found to oxidize a variety of alcohols under neutral conditions (in the absence of base) to yield the corresponding carbonyl compounds, catalytically with a markedly high turnover number.The oxidation yields were promoted remarkably depending upon the presence of lipophilic substituents, particularly due to the presence of longer alkyl groups at the 10-position.These catalysts are so stable that the oxidation reaction proceeds until the substrate is exhausted.

Flavins as potential antimalarials. 2. 3-Methyl-10-(substituted-phenyl)flavins

A series of 3-methyl-10-(substituted-phenyl)flavins was prepared and tested for antimalarial activity against the lethal parasite Plasmodium vinckei in mice. Several of these analogues were found to be effective antimalarial agents. A quantitative structure-activity relationship study was undertaken with 44 analogues and no satisfactory relationship could be established.