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Upstream product

• 73987-32-3 2-methylmercapto-3-phenyl-4(3H)-quinazolinone 
• 18741-31-6 1-[(3,4-dihydro-4-oxo-3-phenyl-2-quinazolinyl)thio]-2-propanone 
• 28831-35-8 (3-phenyl-4-oxo-3,4-dihydroquinazolin-2-ylsulfanyl)acetic acid ethyl ester 
• 18741-24-7 2-mercapto-3-phenyl-3H-quinazolin-4-one 
• 250690-57-4 ethyl α-fluoro-α-[(3,4-dihydro-4-oxo-3-phenyl-2-quinazolinyl)thio]acetate 

Relevant academic research and scientific papers

Electrolytic partial fluorination of organic compounds. 35. Anodic fluorination of 2-pyrimidyl, 2-pyridyl, and 2-quinazolinonyl sulfides

Highly regioselective electrochemical fluorination of 2-pyrimidyl sulfides having an electron-withdrawing group (EWG) at the position α to the sulfur atom was successfully carried out using Et4NF·nHF (n = 3, 4) or Et3N·3HF as a supporting electrolyte and a fluoride ion source in 1,2- dimethoxyethane (DME) in an undivided cell. 2-Methylthiopyrimidine devoid of an EWG was also selectively fluorinated in DME to provide 2- (fluoromethylthio)pyrimidine in a moderate yield as 63%, while corresponding 2-methylthiopyridine was less selectively fluorinated in lower yield along with α,α-difluorinated product. In contrast, the corresponding 2- quinazolinonyl sulfides underwent similarly α-fluorination along with unexpected ipso-fluorination through anodic desulfurization.