727-79-7

Usage

Uses

Used in Pharmaceutical Industry:
Uridine, 5-fluoro-4-thiois used as a precursor for the development of new drugs, particularly for the treatment of neurological disorders. Its unique structure and biological activity make it a valuable tool for understanding the molecular mechanisms involved in RNA and DNA processes, which can aid in the design of novel therapeutic agents.
Used in Biochemical Research:
Uridine, 5-fluoro-4-thiois used as a research compound in biochemical studies to investigate the properties and functions of nucleic acids, such as RNA and DNA. Its modified structure allows researchers to explore the effects of specific modifications on the behavior and interactions of these molecules, contributing to a deeper understanding of their roles in biological systems.
Used in Drug Design:
Uridine, 5-fluoro-4-thiois used as a starting point for the design of novel therapeutic agents. Its unique structure and biological activity provide insights into the development of new drugs with improved efficacy and selectivity for targeted diseases, particularly in the treatment of neurological disorders.

Upstream product

• 55474-11-8 (2R,3R,4R,5R)-2-(acetoxymethyl)-5-(5-fluoro-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-3,4-diyl diacetate 
• 316-46-1 5-fluorouridine 

Relevant academic research and scientific papers

Photoinduced fluorescent cross-linking of 5-chloro- and 5-fluoro-4-thiouridines with thymidine

(Chemical Equation Presented) Two highly fluorescent, thermally stable diastereomeric photoadducts, 3a,b, are formed when either 5-chloro-4- thiouridine, 1, or 5-fluoro-4-thiouridine, 2, are photoexcited with 366 nm UV light in the presence of thymidine (T). 5-Fluoro-4-thiouridine, 2, exhibits photoreactivity much higher than that of the 5-chloro derivative 1. In both cases the photoreaction is very clean, leading to highly eficient conversion of the 5-halogeno-4-thiouridine (1, 2) and T to photoadducts 3a,b. The identity and structure of 3a was confirmed using mass spectrometry and 2-D NMR. The epimeric relationship of 3a,b was established by UV circular dichroism spectroscopy. The geometry of the fluorescent photoadduct is consistent with formation of an interstrand cross-link in a DNA duplex if 1 or 2 is flanked by T in an opposite strand.

Systematic assignment of NMR spectra of 5-substituted-4-thiopyrimidine nucleosides

Unambiguous characterization of 5-substituted-4-thiopyrimidine nucleosides (ribonucleosides and 2'-deoxynucleosides) was performed using NMR spectroscopy. Assignments of all proton and carbon signals of 5-bromo-4-thiouridine and related nucleosides were systematically carried out and firmly established by COSY and HMQC techniques. The NMR data of various 4-thiopyrimidine nucleosides are compared, and the key contributing factors discussed. The approach presented here is applicable to other modified nucleosides and nucleotides, as well as nucleobases. Copyright

Anti-HCV nucleoside derivatives

The present invention comprises novel and known purine and pyrimidine nucleoside derivatives which have been discovered to be active against hepatitis C virus (HCV). The use of these derivatives for the treatment of HCV infection is claimed as are the novel nucleoside derivatives disclosed herein.