7270-98-6Relevant academic research and scientific papers
Ruthenium-catalyzed tandem-isomerization/asymmetric transfer hydrogenation of allylic alcohols
Slagbrand, Tove,Lundberg, Helena,Adolfsson, Hans
, p. 16102 - 16106 (2014)
A one-pot procedure for the direct conversion of racemic allylic alcohols to enantiomerically enriched saturated alcohols is presented. The tandem-isomerization/ asymmetric transfer hydrogenation process is efficiently catalyzed by [{Ru(p-cymene)Cl2}2] in combination with the a-amino acid hydroxyamide ligand 1, and performed under mild conditions in a mixture of ethanol and THF. The saturated alcohol products are isolated in good to excellent chemical yields and in enantiomeric excess up to 93%.
