72702-95-5

Usage

Uses

Used in Pharmaceutical Industry:
STATIL is used as an aldose reductase inhibitor for preventing diabetes-induced alterations in the cardiovascular system. Its selectivity for aldose reductase 2 over aldose reductase 1 makes it a promising candidate for the development of treatments targeting diabetes-related complications.
Used in Cancer Treatment:
STATIL is used as an inhibitor to suppress cell cancer growth. Its ability to block the conversion of glucose to sorbitol may contribute to its potential application in cancer therapy, as altered glucose metabolism is a common characteristic of cancer cells.
Used in Research and Development:
STATIL is used as a research tool for studying the role of aldose reductase in various biological processes. Its selectivity for different aldose reductase isoforms allows researchers to investigate the specific functions and implications of these enzymes in cellular metabolism and disease progression.
Used in Drug Development:
STATIL is used as a lead compound in the development of new drugs targeting aldose reductase. Its inhibitory properties and selectivity make it a valuable starting point for designing more potent and selective inhibitors with potential therapeutic applications in diabetes and cancer.

InChI:InChI=1/C17H12BrFN2O3/c18-11-6-5-10(14(19)7-11)9-21-17(24)13-4-2-1-3-12(13)15(20-21)8-16(22)23/h1-7H,8-9H2,(H,22,23)

Upstream product

• 76283-09-5 4-bromo-2-fluorobenzyl bromide 
• 25947-13-1 ethyl 1,2-dihydro-1-oxophthalazin-4-ylacetate 

Downstream Products

• 1226760-14-0 2-(4-bromo-2-fluorobenzyl)-4-(2-(4-methylpiperazin-1-yl)-2-oxoethyl)phthalazin-1(2H)-one 
• 1226760-13-9 2-(2-(4-bromo-2-fluorobenzyl)-1,2-dihydro-1-oxo-phthalazin-4-yl)-N-(5-nitrothiazol-2-yl)acetamide 
• 1226760-22-0 2-(4-bromo-2-fluorobenzyl)-4-(2-oxo-2-(2-(4-pyridin-2-yl)piperazin-1-yl)ethyl)phthalazin-1(2H)-one 
• 1226760-21-9 2-(4-bromo-2-fluorobenzyl)-4-(2-(4-benzylpiperazin-1-yl)-2-oxoethyl)phthalazin-1(2H)-one 
• 1226760-19-5 2-(4-bromo-2-fluorobenzyl)-4-(2-(4-(4-methoxyphenyl)piperazin-1-yl)-2-oxoethyl)phthalazin-1(2H)-one 
• 1226760-12-8 2-(2-(4-bromo-2-fluorobenzyl)-1,2-dihydro-1-oxophthalazin-4-yl)-N-(6-nitrobenzo[d]thiazol-2-yl)acetamide 
• 1226760-02-6 2-(2-(4-bromo-2-fluorobenzyl)-1,2-dihydro-1-oxo-phthalazin-4-yl)-N-(4-chlorophenyl)acetamide 
• 1226760-23-1 2-(4-bromo-2-fluorobenzyl)-4-(2-oxo-2-(1-(4-piperonoyl)piperazin-1-yl)ethyl)phthalazin-1(2H)-one 
• 1226760-00-4 2-(2-(4-bromo-2-fluorobenzyl)-1,2-dihydro-1-oxo-phthalazin-4-yl)-N-phenylacetamide 
• 1226760-16-2 2-(4-bromo-2-fluorobenzyl)-4-(2-(4-(4-fluorophenyl)piperazin-1-yl)-2-oxoethyl)phthalazin-1(2H)-one 
• 1226760-20-8 2-(4-bromo-2-fluorobenzyl)-4-(2-(4-(3-methoxyphenyl)piperazin-1-yl)-2-oxoethyl)phthalazin-1(2H)-one 
• 1226760-18-4 2-(4-bromo-2-fluorobenzyl)-4-(2-(4-(3-(trifluoromethyl)phenyl)piperazin-1-yl)-2-oxoethyl)phthalazin-1(2H)-one 
• 1226760-03-7 2-(2-(4-bromo-2-fluorobenzyl)-1,2-dihydro-1-oxo-phthalazin-4-yl)-N-(4-bromophenyl)acetamide 
• 1226760-04-8 2-(2-(4-bromo-2-fluorobenzyl)-1,2-dihydro-1-oxo-phthalazin-4-yl)-N-(2-trifluoromethylphenyl)acetamide 

Relevant academic research and scientific papers

Synthesis and antimycobacterial evaluation of novel phthalazin-4- ylacetamides against log- and starved phase cultures: Research article

Twenty four novel 2-[3-(4-bromo-2-fluorobenzyl)-4-oxo-3,4-dihydro-1- phthalazinyl]acetic acid amides were synthesized from phthalic anhydride and were subjected to in vitro and in vivo evaluation against log- and starved phase of mycobacterial species and

USE OF SUBSTITUTED 2 PHENYLBENZIMIDAZOLES AS MEDICAMENTS

The present invention relates to the use of a substituted 2-phenylbenzimidazole of formula I wherein R1, R2, R3, R 4, R5 and m have the meanings given in the claims, for the preparation of a medicament for the treatment or prevention of diseases involving glucagon receptors, as well as new compounds of formula I wherein R1 is a group of formula