72719-13-2Relevant academic research and scientific papers
Identification, Structure determination and Synthesis of Until now Unknown Amino Acid Conjugates from Human Urine I
Spiteller, Michael,Spiteller, Gerhard
, p. 249 - 258 (1980)
The conjugates of glycine with furan 2.5-dicarboxylic acid and of picolinic acid as well as a conjugate of pyroglutamic acid with phenylacetic acid, previously unknown as natural metabolites, were detected to be normal metabolites in human urine. - Keywords: Amino acid conjugates; Conjugates of amino acids; Metabolic profiling
Straightforward and facile approach toward the n-derivatization of pyroglutamates through mitsunobu reaction: Synthesis of N-alkyl/N-acyl pyroglutamates
Panday, Sharad Kumar,Prasad, Jagdish,Pathak, Manoher Bhushan
experimental part, p. 3654 - 3661 (2011/10/09)
Pyroglutamates have been acknowledged as useful chiral synthons for the synthesis of many bioactive natural products, ACE inhibitors, and conformationally constrained peptides. Though the reactivity differences between two differential carbonyl groups have been well exploited, there is still a dearth of publications on the N-alkylation/acylation of native pyroglutamate as such, due to the relatively low reactivity of NH of pyroglutamates. In the present communication, we report for the first time a simple and efficient methodology for the N-alkylation/acylation of pyroglutamate via Mitsunobu reaction. Copyright Taylor & Francis Group, LLC.
