72725-71-4Relevant academic research and scientific papers
Nickel-Catalyzed Michael Additions of β-Dicarbonyls
Nelson, John H.,Howells, Peter N.,DeLullo, George C.,Landen, George L.,Henry, Ronald A.
, p. 1246 - 1249 (2007/10/02)
Bis(2,4-pentanedionato)nickel(II) is found to be a mild, efficient, and simple to use catalyst for the Michael additions of β-dicarbonyls.Yields are higher than with traditional strongly basic catalysts, unwanted side reactions are reduced, and workup procedures are greatly simplified.The reactions appear to be quite general as β-diketones, β-keto esters, β-keto amides, and β-diesters are all found to react.A rational mechanism which suggests further research is presented.
