72726-49-9

Upstream product

• 77086-38-5 ketene t-butyldimethylsilyl methyl acetal 
• 822-67-3 Cyclohex-2-enol 
• 18162-48-6 tert-butyldimethylsilyl chloride 
• 72726-46-6 tert-butyl(dimethyl)(phenylseleno)silane 
• 286-20-4 cyclohexane-1,2-epoxide 
• 72726-45-5 tert-butyldimethylsilyl iodide 

Downstream Products

• 73795-22-9 3-t-butyldimethylsiloxy-2-phenylselenocyclohexanone 
• 102922-54-3 (1β,2α)-2-(oxy)-1-cyclohexanol 
• 102922-54-3 cis-2-(tert-butyldimethylsilyloxy)-1-cyclohexanol 
• 116565-14-1 (1R^*,3R^*)-3-<(tert-butyldimethylsilyl)oxy>cyclohexanol 
• 116565-14-1 (1S^*,3R^*)-3-<(tert-butyldimethylsilyl)oxy>cyclohexanol 
• 70810-37-6 3-(tert-butyldimethylsilyloxy)-1-(phenylsulfonyl)cyclohexene 
• 579488-71-4 methyl 3-(2-(tert-butyldimethylsilyloxy)cyclohexyl)-2-(2-pyridylsulfanyl)propanoate 
• 579488-74-7 methyl 3-(3-(tert-butyldimethylsilyloxy)cyclohexyl)-2-(2-pyridylsulfanyl)propanoate 
• 80684-13-5 3-t-butyldimethylsiloxycyclohexanone 
• 125488-60-0 tert-Butyl-(3-isocyano-cyclohex-2-enyloxy)-dimethyl-silane 
• 125488-55-3 tert-Butyl-((2R,3S)-2-iodo-3-isocyano-cyclohexyloxy)-dimethyl-silane 
• 1384870-20-5 C₁₅H₂₀N₂O₃S 

Relevant academic research and scientific papers

PYRAZOLOPYRIMIDINE INHIBITORS OF IRAK4 ACTIVITY

The present invention relates to pyrazolopyrimidine inhibitors of IRAK4 of formula (I) and provides compositions comprising such inhibitors, as well as methods therewith for treating IRAK4-mediated or -associated conditions or diseases.

Copper-Catalyzed γ-Selective and Stereospecific Allylic Cross-Coupling with Secondary Alkylboranes

The scope of the copper-catalyzed coupling reactions between organoboron compounds and allylic phosphates is expanded significantly by employing triphenylphosphine as a ligand for copper, allowing the use of secondary alkylboron compounds. The reaction proceeds with complete γ-E-selectivity and preferential 1,3-syn stereoselectivity. The reaction of γ-silicon-substituted allylic phosphates affords enantioenriched α-stereogenic allylsilanes.

FUSED HETEROAROMATIC PYRROLIDINONES

Disclosed are compounds of Formula 1, and pharmaceutically acceptable salts thereof, wherein G, L1, L2, R1, R2, R3, and R4 are defined in the specification. This disclosure also relates to materials and methods for preparing compounds of Formula 1, pharmaceutical compositions containing them, and their use for treating disorders, diseases, and conditions involving the immune system and inflammation, including rheumatoid arthritis, hematological malignancies, epithelial cancers (i.e., carcinomas), and other disorders, diseases, and conditions for which inhibition of SYK is indicated.

Total synthesis of echinopines A and B

Eohinopines A and B [(+)-1 and (+)-2], two naturally occurring compounds characterized with a unique [3.5.5.7] carbon framework, have been synthesized In both enantiomeric and racemic forms. Their total synthesis Involves a novel intramolecular rhodium-catalyzed cyclopropanation (4 →16) and a samarium dilodide-medlated ring closure (3 → 37).

Syntheses of seven-membered rings: Ruthenium-catalyzed intramolecular [5+2] cycloadditions

The Ru-catalyzed intramolecular [5+2] cycloaddition of cyclopropylenynes is investigated with respect to the regio- and diastereoselectivity as well as the functional group compatibility of the reaction. Evidence for the mechanism as occurring through a ruthenacyclopentene intermediate is elucidated from 1) the study of the diastereoselectivity of the cycloaddition; 2) the effect of variation of substituents on the regioselectivity of cyclopropyl bond cleavage in 1,2-trans- and 1,2-cis-disubstituted cyclopropanes and 3) examples that clearly do not involve ruthenacyclohexene as intermediates as products still incorporate the cyclo propyl moiety. The scope and limitations of the Ru-catalyzed cycloaddition are discussed and compared with the Rh-catalyzed reaction. The potential power of this methodology towards natural product total synthesis is demonstrated by the formation of several polycyclic systems with the chosen reaction conditions and readily available cyclopropylenyne substrates.

One-pot rhodium(I)-catalyzed hydroboration of alkenes: Radical conjugate addition

B-Alkylcatecholboranes, prepared by rhodium-(I)-catalyzed hydroboration of alkenes, are suitable radical precursors for conjugate addition to activated olefins. This procedure proved to be particularly useful for the control of the regio- and chemoselectivity of such tandem processes. Enantioselective hydroboration has also been successfully coupled with radical chain reaction in a one-pot process.

Direct substitution of secondary allylic alcohols with O-silylated ketene acetals in 3.0 M lithium perchlorate-diethyl ether - An alternative to the [1,3] sigmatropic rearrangement of allyl vinyl ethers

Allylic alcohols of type 1 undergo unprecedented substitution with O-silylated ketene acetals in 3.0 M lithium perchlorate-diethyl ether.

Silyl Halides from (Phenylseleno)silanes. Reaction with Oxiranes and Alcohols To Give Hydrolytically Stable Silyl Ethers.

The preparation of (phenylseleno)silanes and their reactions with halogens (Cl2, Br2, I2) to give silyl halides and diphenyl diselenide are described.Highly hindered tert-butyldimethyl and tert-butyl diphenylsilyl halides were easily prepared.The reaction of silyl bromides and iodides with oxiranes followed by diazabicyclononane treatment gave allylic alcohol silyl ethers.Tertiary alcohols reacted rapidly with silyliodides to give hydrolytically stable silyl ethers.Treatment of the silyl ethers with tetra-n-butylammonium fluoride gave the free alcohols withoutrearrangement or isomerization.

Electrophilic Conversion of Oxiranes to Allylic Alcohols with tert-Butyldimethylsilyl Iodide

tert-Butyldimethylsilyl iodide (I) is prepared from the reaction of iodine with (phenylseleno)-tert-butyldimethylsilane in acetonitrile.The reaction of oxiranes with 1 followed by treatment with 1,5-diazabicyclonon-5-ene gives accetable yields of allylic alcohols isolated as their tert-butyldimethylsilyl ethers.Ring opening involves cleavage of the bond to the more highly substituted carbon.