72733-80-3Relevant academic research and scientific papers
New s-block complexes of 1,10-phenanthroline and 1,3-benzothizole-2-thiolate inhibit urease in silico and in vitro
Shah, Syed Raza,Shah, Zarbad,Khiat, Mohammed,Halim, Sobia A.,Khan, Ajmal,Hussain, Javid,Csuk, Rene,Anwar, Muhammad U.,Al-Harrasi, Ahmed
, (2020)
The coordination chemistry of 1,10-phenanthroline (phen) and sodium 1,3-benzothiazole-2-thiolate (SBT) with selected s-block elements has been investigated. Four metal complexes were prepared and their structures were characterized using a variety of analytical techniques including infrared, UV–visible, 1H NMR and 13C NMR spectroscopies, elemental analysis, mass spectrometry and single-crystal X-ray diffraction. The reactions of phen and SBT with M(X)n (M = K(I), Cs(I), Mg(II), Sr(II); X = OH?, CO3?, Cl?; n = 1, 2) in MeOH–H2O yielded one-dimensional chains of both potassium [K2(phen)2(BT)2(H2O)4]n (1) and caesium [Cs(phen)(BS)(H2O)]n (2) (where BT = 1,3-benzthiazole-2-thiolate and BS = 1,3-benzthiazole-2-sulfinothiolate) and mononuclear complexes of both magnesium {[Mg(phen)(H2O)4](BT)2·phen} (3) and strontium {[Sr(phen)2(H2O)4](BT)2} (4). In these complexes, phen binds via an N,N′ chelate pocket, while the monoanonic BT? ligands either coordinate in a bidentate fashion (in the case of 1) or remain uncoordinated (in the case of 3 and 4). In complex 2, SBT ligand was oxidized in situ into a new BS ligand. The sulfinothiolate oxygen atoms in BS coordinate with caesium in a tridentate fashion. Complexes 1–4 were evaluated against urease for enzyme inhibition. The complexes displayed significant inhibition with IC50 values in the range 10.8–45.8 μM. In order to examine the structure–activity relationship, the complexes were docked at the active site of urease. Docking results clearly demonstrate the binding of each complex within the active site of the enzyme.
IODOMETRIC DETERMINATION OF 2-MERCAPTOBENZTHIAZOLE BY COULOMETRIC TITRATION
Kucera, Zdenek,Karlik, Milan,Krofta, Jiri
, p. 588 - 593 (2007/10/02)
The optimum conditions were found for the determination of 2-mercaptobenzthiazole (MBT) by coulometric titration with the generated iodine using biamperometric indication of the titration end point.Use is made of the oxidation to the disulphide (n=1) and to benzthiazole-2-sulphinate (n = 4) in the regions pH 4.5-8.5 and 10-12, respectively.Eight repeated titrations to the disulphide gave the relative standard deviations 0.27percent and 1.23percent in the determination of 1 657 and 33.5 μg MBT, respectively, seven repeated titrations of 419 μg MBT to benzthiazole-2-sulphinate afforded results with the relative standard deviation 0.34percent.
