727364-84-3

Upstream product

• 104-87-0 4-methyl-benzaldehyde 
• 141-97-9 ethyl acetoacetate 
• 61-82-5 3-amino-1,2,4-triazole 
• 61-82-5 3⁽⁵⁾-amino-1,2,4-triazole 

Relevant academic research and scientific papers

Agar-entrapped sulfonated DABCO: Agelly acidic catalyst for the acceleration of one-pot synthesis of 1,2,4-triazoloquinazolinone and some pyrimidine derivatives

In this project, a recently synthesized DABCO-based catalyst is entrapped in agar to reduce its moisture sensitivity leading to enhancement of its stability and catalytic activity. After preparation and identification this new reagent is used as an efficient and environmentally safe catalyst for the preparation of 1, 2, 4-triazoloquinazolinone and some pyrimidine derivatives. This method is accompanied with some superiorities such as, simple operation, mild and green conditions, use of low cost and non-hazardous natural material, short reaction times, easy preparation methods and simple work-up procedures. The prepared catalyst can be re-used for several times in all of the studied reactions without any appreciable loss in its activity.

Design and synthesis of nickel tetra‐2,3‐pyridiniumporphyrazinato trinitromethanide as an influential catalyst and its application in the synthesis of 1,2,4-triazolo based compounds

The facile and benign syntheses of [1,2,4]triazolo[5,1-b]quinazolines and [1,2,4]triazolo[1,5-b]pyrimidines were studied using novel nickel tetra‐2,3‐pyridiniumporphyrazinato trinitromethanide [Ni(TPPAH)][C(NO2)3]4 as an e

Efficiency of NaHSO4 modified periodic mesoporous organosilica magnetic nanoparticles as a new magnetically separable nanocatalyst in the synthesis of [1,2,4]triazolo quinazolinone/pyrimidine derivatives

Immobilized NaHSO4 on core/shell phenylene bridged Periodic mesoporous organosilica magnetic nanoparticles (γ-Fe2O3@Ph-PMO-NaHSO4) as a new acidic magnetically separable nanocatalyst was successfully prepared in three steps: (i) preparation of γ-Fe2O3 nanoparticles by a precipitation method, (ii) synthesis of an organic-inorganic periodic mesoporous organosilica structure with phenyl groups on the surface of γ-Fe2O3 magnetic nanoparticles (MNPs) and (iii) finally adsorption of NaHSO4 on periodic mesoporous organosilica (PMO) network. The results of N2 adsorption-desorption isotherms, XRD and TEM showed formation of the Periodic mesoporous organosilica magnetic nanocomposite with the uniform size up to 15 nm. The efficiency of the new catalyst was evaluated in promoting the synthesis of [1,2,4]triazolo quinazolinone/pyrimidine derivatives as important biologically active compounds. Eco-friendly protocol, high yields, short reaction times, reusability of the catalyst and easy and quick isolation of the products are the main advantages of this procedure.

A simple and convenient synthesis of [1,2,4]triazolo/benzimidazolo quinazolinone and [1,2,4]triazolo[1,5-a]pyrimidine derivatives catalyzed by DABCO-based ionic liquids

DABCO-based ionic liquids were utilized for the preparation of [1,2,4]triazolo/benzimidazolo quinazolinone and [1,2,4]triazolo[1,5-a]pyrimidine derivatives in the adequate procedures. These methods involve three-component reaction between aldehydes, β-dik

Three-component uncatalyzed eco-friendly reactions for one-pot synthesis of 4,7-dihydro[1,2,4]triazolo[1,5-a]pyrimidine derivatives

A three-component system of one-pot synthesis of [1,2,4]triazolo[1,5-a] pyrimidine derivatives using condensation of 1,3-dicarbonyl compounds, aldehydes, and 5-amino[1,2,4]triazole in ethanol without any catalyst was reported in high yields via simple, efficient, and environmentally friendly process. The method reported herein considered a green process; this method has significant advantages of simple workup procedure, excellent yield, minimal environmental pollution, and short reaction time over classical reported methods.