727382-81-2

Upstream product

• 105-13-5 4-Methoxybenzyl alcohol 
• 609-15-4 ethyl 2-chloro-3-oxo-butyrate 
• 638-07-3 ethyl (2-chloroaceto)acetate 

Downstream Products

• 1240195-08-7 (E/Z)-ethyl 4-(4-methoxybenzyloxy)-3-(methylamino)but-2-enoate 
• 1265909-14-5 C₁₆H₁₉NO₄ 

Relevant academic research and scientific papers

A Stereoselective Synthesis of the Carbon Backbone of Phoslactomycin B

A convergent synthesis of the entire carbon framework of phoslactomycin B is disclosed. An initial route aimed to create the C-8 tetrasubstituted stereocentre through regioselective intermolecular coupling between an internal alkyne and an allyl silyl ether, adopting Trost's protocol, followed by [2,3] sigmatropic rearrangement. But this was not successful. In a second approach, a propargylic sulfide was rearranged to give an unsaturated ketone. This was then treated with lithio acetonitrile to create the C-8 stereocentre selectively. The C-4 and C-5 stereocentres were introduced by a non-Evans syn-aldol reaction using Crimmins's protocol. The C-9 and C-11 carbinol centres were created by asymmetric transfer hydrogenation. The (Z,Z)-diene moiety was introduced by partial reduction of a diyne following Hansen's modification of the Boland reduction reaction.

Synthesis of indolequinones from bromoquinones and enamines mediated by Cu(OAc)2H2O

A Cu(II)-mediated synthesis of indolequinones from the corresponding bromoquinones and enamines is reported. The key oxidative cyclization proceeds in good yield for a broad range of substrates and can be performed on a multigram scale, allowing access to biologically interesting structures.

Pyrid-2-one derivatives and methods of use

Selected compounds are effective for treatment of diseases, such as cell proliferation or apoptosis mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable derivatives thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving stroke, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.