72739-49-2Relevant academic research and scientific papers
Inhibition of Histamine-Induced Gastric Secretion by Flavone-6-carboxylic Acids
Pfister, Juerg R.,Wymann, Walter E.,Schuler, Margery E.,Roszkowski, Adolph P.
, p. 335 - 338 (2007/10/02)
Twenty-five flavone-6-carboxylic acids were synthesized and tested as to their ability to inhibit histamine-induced gastric acid secretion in the rat. 3-Isopropoxy-4'-methoxyflavone-6-carboxylic acid (41) showed consistent oral activity while being devoid of any other noteworthy pharmacological effects.In vitro, this compound was found to be inactive as a histamine H2 antagonist, and its mode of action remains unknown.
